The effect of β-cyclodextrin in the photochemical stability of propranolol hydrochloride in aqueous solution

Tathiane Lilian Ansolin, Reinaldo Aparecido Bariccatti, Mauricio Ferreira da Rosa, Cleber Antonio Lindino

Resumo


The degradation of propranolol hydrochloride (1-isopropylamino-3-(naphthoxy)-2-propranolol) in an aqueous solution was analyzed when irradiated by light UV, with and without β-cyclodextrin. There was an increase in the compound´s photostability in nanocavity when compared with the drug without the cyclodextrins’ cavity. First order kinetic model was employed for the degradation of propranolol in aqueous media and in cyclodextrins’ cavity. The kinetic parameter was obtained by the drug´s absorption and electronic fluorescence. As a rule, encapsulation of propranolol in β-cyclodextrin decreases photodegradation speed by 53%.

 


Palavras-chave


nanocavity; drug; photochemical

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DOI: http://dx.doi.org/10.4025/actascitechnol.v36i2.17554





ISSN 1806-2563 (impresso) e ISSN 1807-8664 (on-line) e-mail: actatech@uem.br

  

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