<b>Protective effects of ethanolic extract from the red algae <i>Amansia multifida</i> on experimental inflammation, nociception and seizure experimental models

  • Gislei Frota Aragão Universidade Estadual de Ceará
  • Dayanne Terra Tenório Nonato Universidade Estadual de Ceará
  • Edson Lopes da Ponte Centro Universitário Christus
  • Jonathan Rodrigues Sales Universidade Estadual do Ceará
  • Daniel Barroso Alencar Universidade Estadual do Ceará
  • Silvana Saker Sampaio Universidade Estadual do Ceará
  • Edna Maria Camelo Chaves Universidade Estadual de Ceará
  • Ana Maria Sampaio Assreuy Universidade Estadual do Ceará
Palavras-chave: acute inflammatory process, antinociception, epilepsy, red seaweed

Resumo

This study aimed to investigate the EEAm effect in mice models of nociception, inflammation and in behavioral tests evaluating the central nervous system. EEAm had inhibitory effects in the following tests: acetic acid-induced writhing (78%); formalin (62% - inflammatory phase); open field (46%). EEAm increased the nociceptive latency (56%) in tail flick test and increased the death-latency by 36% in the pentylenetetrazole-induced seizure model. Moreover, EEAm inhibited paw edema (82%) and peritonitis (45%) induced by carrageenan. In conclusion, EEAm presents antinociceptive, anti-inflammatory and anticonvulsant effects involving peripheral and central-acting mechanisms in mice.

 

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Publicado
2016-12-20
Como Citar
Aragão, G. F., Nonato, D. T. T., Ponte, E. L. da, Sales, J. R., Alencar, D. B., Sampaio, S. S., Camelo Chaves, E. M., & Assreuy, A. M. S. (2016). <b>Protective effects of ethanolic extract from the red algae <i>Amansia multifida</i&gt; on experimental inflammation, nociception and seizure experimental models. Acta Scientiarum. Biological Sciences, 38(4), 465-471. https://doi.org/10.4025/actascibiolsci.v38i4.32361
Seção
Morfofisiologia Animal

 

0.6
2019CiteScore
 
 
31st percentile
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0.6
2019CiteScore
 
 
31st percentile
Powered by  Scopus