In vitro binding capacity of free bilirubin by aqueous extract of Marrubium vulgare L.

  • Sara Stayeb Mascara University https://orcid.org/0000-0002-4554-1199
  • Mahmoud Adel Chabane Mascara University
  • Fadhéla Boukada Mascara University
  • Asmaa Belgharbi Mascara University
  • Zineb Boualem Mascara University
  • Soumaya Bouchekara Mascara University
  • Djamila Boukraa Mascara University

Resumo

Marrubium vulgare L. (MVL.) has been traditionally used to treat kernicterus. However, the anti-jaundice effects and mechanisms of MVS. on free bilirubin remain poorly understood. The present study assesses the anti-jaundice effect of the aqueous extract of MVL, by measuring the percentage of adsorption (binding) of this extract on plasmatic free bilirubin obtained from kernicterus newborns (n = 40). The plant’s aerian party and leaf pouder histological and phytochemical properties of MVL were examined. Our results show that dry aqueous extract of MVL contains total phenols (51.5 ± 0.40 mg EAG g-1), condensed tannins (14.7 ± 0.49 mg ECAT g-1) and flavonoids (25.33 ± 0.41 mg ECAT g-1). Histological examination showed that both the surfaces of leave and stems are covered by a protective hair; glandular and non-glandular trichomes which produced various secondary metabolites. Free bilirubin was significantly bound by the aqueous extract of MVL at different concentrations (250-1250 µg ml-1) to the extent of (33.6 - 54.61%). In the light of these preliminary findings and future experimental studies, it indicates that this plant may be used as a source of therapeutic agent for kernicterus and can be an alternative treatment to the currently available treatments such as phototherapy and exsanguino-transfusion, which have serious short and long term complications.

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Publicado
2025-04-14
Como Citar
Stayeb, S., Mahmoud Adel Chabane, Boukada, F., Belgharbi, A., Boualem, Z., Bouchekara, S., & Boukraa, D. (2025). In vitro binding capacity of free bilirubin by aqueous extract of Marrubium vulgare L. Acta Scientiarum. Biological Sciences, 47(1), e73941. https://doi.org/10.4025/actascibiolsci.v47i1.73941
Seção
Biotecnologia

 

0.6
2019CiteScore
 
 
31st percentile
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0.6
2019CiteScore
 
 
31st percentile
Powered by  Scopus