<b>Physical and chemical analysis of commercial nystatin</b> - doi: 10.4025/actascihealthsci.v35i2.12769

  • Edeilza Gomes Brescansin Universidade Estadual de Maringá
  • Márcia Portilho Universidade Estadual de Maringá
  • Francisco Benedito Teixeira Pessine Universidade de Campinas
Palavras-chave: nystatin, physical and chemical analyses, analytical control

Resumo

Nystatin (NYS) is a fermentation-produced antibiotic of the polyene group. Commercial NYS is a mixture of compounds named NIS A1, A2 and A3. Current analysis undertook physical and chemical analyses in two samples of commercial nystatin (NYS I and NYS II). Moisture (Karl Fischer), spectroscopic (IR, UV and fluorescence) and thermal analyses (TGA and DSC) were conducted. The moisture was respectively 9.2% and 8.8% for samples I and II. Absorption spectrum in the UV/VIS region had a vibronic structure with three lmax.. The mirror image rule was not complied with in the fluorimetric analysis. Spectroscopy analysis in the IV region indicated that samples showed spectra similar one to another, analogous to crystal type A. Thermal analyses by DSC provided a wide, single endothermal peak and, therefore, similarities among the samples. DTG shows that samples undergo decomposition at three phases within the temperature range under analysis. Results show that samples are impure and not polymorphic, constituted by a mixture of the compounds A1, A2 and A3.

 

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Biografia do Autor

Edeilza Gomes Brescansin, Universidade Estadual de Maringá
Tem experiência na área de Farmácia química, atuando principalmente nos seguintes temas: Controle de qualidade de fármacos e medicamentos, estabilidade de medicamentos, nanotecnologia, encapsulação de fármacos em lipossomas.
Publicado
2013-06-14
Como Citar
Brescansin, E. G., Portilho, M., & Pessine, F. B. T. (2013). <b>Physical and chemical analysis of commercial nystatin</b&gt; - doi: 10.4025/actascihealthsci.v35i2.12769. Acta Scientiarum. Health Sciences, 35(2), 215-221. https://doi.org/10.4025/actascihealthsci.v35i2.12769
Seção
Farmácia

0.3
2019CiteScore
 
 
8th percentile
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0.3
2019CiteScore
 
 
8th percentile
Powered by  Scopus