<b>The importance of coating standardization in gastro-resistant capsules produced in magistral pharmacy</b> - doi: 10.4025/actascihealthsci.v35i2.14581

  • Suelen Cristina Franco Universidade Estadual de Londrina
  • Flávia Cristina da Silva Universidade Estadual de Londrina
  • Marcela Maria Baracat Universidade Estadual de Londrina
  • Rúbia Casagrande Universidade Estadual de Londrina
  • Janice Aparecida Rafael Faculdade de Ensino Superior Dom Bosco
  • Daniela Cristina de Medeiros Universidade Estadual de Londrina
Palavras-chave: methacrylic acid copolymer, cellulose acetate phthalate, enteric coating, capsules

Resumo

Gastro-resistant capsules are often used for several purposes, such as protection of unstable drugs in acid medium to the action of gastric fluids or protection of the gastric mucosa to irritants drugs. The aim of this study was to verify the variation of preparations of capsules coating with cellulose acetate phthalate and methacrylic acid copolymer, without drug addition, in 7-10% coating concentrations, prepared manually with four or five immersions in tested coating solution. Results were analyzed considering the formulation’s disintegration test. Within the context of formulations under analysis, it was observed that the capsules coated with cellulose acetate phthalate 10% complied with the pharmacopeia’s disintegration specifications. However, capsules coated with methacrylic acid copolymer did not show accordance with the pharmacopeia’s specifications. The results emphasize the need for the standardization of coating methodology.

 

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Publicado
2013-06-14
Como Citar
Franco, S. C., Silva, F. C. da, Baracat, M. M., Casagrande, R., Rafael, J. A., & Medeiros, D. C. de. (2013). <b>The importance of coating standardization in gastro-resistant capsules produced in magistral pharmacy</b&gt; - doi: 10.4025/actascihealthsci.v35i2.14581. Acta Scientiarum. Health Sciences, 35(2), 211-214. https://doi.org/10.4025/actascihealthsci.v35i2.14581
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0.3
2019CiteScore
 
 
8th percentile
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0.3
2019CiteScore
 
 
8th percentile
Powered by  Scopus