Two dimensional finite element estimation of calcium ions in presence fo NCX and Buffers in Astrocytes

Abstract

Sodium calcium exchanger (NCX) plays effective role in signal transduction in most of the nerve cells like neuron, astrocytes. Sodium ion affects the cytosolic calcium concentration label in Astrocytes via various channels. This affects the movement of the nerve impulse from one cell to other cell. In this paper two dimensional model is developedin the form of diffusion equation to study the effect of NCX in presence and negligence of buffer in Astrocytes. Finite element method is employed to solve the problem and simulated in Matlab to estimate the affect of various parameter like flux, diffusion coefficient, buffer concentration, etc.