MACROSCOPIC AND MICROSCOPIC INJURIES OF PATIENTS AFFECT-ED BY COVID-19
Resumo
After the first report of an outbreak of acute respiratory syndrome in China in December 2019, a new coronavirus, severe acute respiratory syndrome - coronavirus 2 (SARS-CoV-2) was identified. Despite to the high number of cases and deaths, limited information is available regarding the pathogenesis and injuries caused by the new coronavirus. This study aims to carry out a literature review concerning the macroscopic and microscopic aspects of the disease, since the progression of the disease is closely related to the viral action and the cellular and tissue response in the lesions caused by it. In conclusion COVID-19 is a disease that can affect all types of body tissues. The lesions affect mainly the pulmonary parenchyma and are usually macroscopically observed as consolidation areas, and histologically as plasmacytic lymphoid interstitial pneumonia and with neutrophil infiltration, already observed lesions outside the lung are mainly due to the inflammatory action of lymphocytes and histiocytes, and to the intense production of cytokines with systemic action
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Referências
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BARRY ROCKX, THIJS KUIKEN, SANDER HERFST, THEO BESTEBROER, MART M. LAMERS, BAS B. OUDE MUNNINK, DENNIS DE MEULDER, GEERT VAN AMERONGEN, JUDITH VAN DEN BRAND, NISREEN M. A. OKBA, DEBBY SCHIPPER, PETER VAN RUN, LONNEKE LEIJTEN, REINA SIKKEMA, ERNST VERSCHOOR, BABS VERSTREPEN, WILLY BOGERS, JAN LANGERMANS, CHRISTIAN DROSTEN, MARTJE FENTENER VAN VLISSINGEN, RON FOUCHIER, RIK DE SWART, MARION KOOPMANS AND BART L. HAAGMANS . Comparative pathogene-sis of COVID-19, MERS, and SARS in a nonhuman primate model , Science v.368, p. 1012–1015, 2020. https://doi.org/10.1126/science.abc4776
BENJAMIN T BRADLEY, HEATHER MAIOLI, ROBERT JOHNSTON, IRFAN CHAUDHRY, SUSAN L FINK, HAODONG XU, BEHZAD NAJAFIAN, GAIL DEUTSCH, J MATTHEW LACY, TIMOTHY WIL-LIAMS, NICOLE YARID, DESIREE A MARSHALL Histopathology and ultra-structural findings of fatal COVID-19 infections in Washington State: a case series. Lancet. p 1 -13, 2020. https://doi.org/10.1016/S0140-6736(20)31305-2
CARVALHO, S.R.; AIRES, M.T.; JUNQUEIRA, J.C.F.; VALLADARES, M.A.; SOUZA, M.T.; FERNANDES, C.R. Doença inflamatória intestinal e COVID-19: Revisão. Residência pediátrica, v.10, p. 1-5, 2020..
CHANDRASHEKAR A, LIU J, MAR-TINOT AJ, MCMAHAN K, MERCA-DO NB, PETER L,. SARS-CoV-2 infec-tion protects against rechallenge in rhesus macaques. Science [Internet]. 2020. Available from: https://www.sciencemag.org/lookup/doi/10.1126/science.abc4776
NANSHAN CHEN, MIN ZHOU, XUANDONG, JIEMINGQU, FENG-YUN GONG, YANG HAN, YANG QIU, JINGLI WANG, YING LIU, YUAN WEI, JIA’ANXIA, TING YU, XINXIN ZHANG, LI ZHANG Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive studynovel coronavirus pneumonia in Wuhan, China:a descriptive study. Lancet v.13, p.395: 507 2020; https://doi.org/10.1016/S0140-6736(20)30211-7
HANLEY, B.; LUCAS, S.B.; YOUD, E.; SWIFT, B.; OSBORN, M. Autopsy in suspected COVID-19 cases. Journal of Clinical Pathology, v. 73, p. 239–242, 2020.
INCIARDI, R.M.; LUPI, L.; ZAC-CONE, G.; ITALIA, L.; RAFFO, M.; TOMASONI, D.; CANI, D.S.; CERINI, M.; FARINA, D.; GAVAZZI, E.; MAROLDI, R.; ADAMO, M.; AM-MIRATI, E.; SINAGRA, G.; LOM-BARDI, C.M.; METRA, M. Cardiac In-volvement in a Patient With Coronavirus Disease 2019 (COVID-19). JAMA car-diology, v.5, n.7, p.819-824.
JOHN M NICHOLLS, LEO L M POON, KAM C LEE, WAI F NG, SIK T LAI, CHUNG Y LEUNG, CHUNG M CHU, PAK K HUI, KONG L MAK, WILINA LIM, KIN W YAN, KWOK H CHAN, NGAI C TSANG, YI GUAN, KWOK Y YUEN, J S MALIK PEIRIS Lung pathology of fatal severe acute res-piratory syndrome. Lancet v. 361, p. 1773–1778. 2003.https://doi.org/10.1016/S0140-6736(20)30211-7
JOTHIMANI, D.; VENUGOPAL, R.; ABEDIN, M.F.; KALIAMOORTHY, I.; RELA, M. COVID-19 and Liver, Jour-nal of Hepatology,In Press, 2020,.
CHEN, L.; DENG, C.; CHEN, X.; ZHANG, X.; CHEN, BO.; YU, H.; QIN, Y.; XIAO, K.; ZHANG, H.; SUN, X. Ocular manifestations and clinical charac-teristics of 534 cases of COVID-19 in China: A cross-sectional study. MedRxiv, In Press, 2020
MCGONAGLE, DENNIS, O’DONNELL, JAMES S, SHARIF, KASSEM, EMERY, PAUL, BRIDGEWOOD, CHARLES Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia. Lancet Rheumatology v-2: p. 437–445, 2020. https://doi.org/10.1016/S0140-6736(20)30211-7
NAICKER, S.; YANG, C.W.; HWANG, S.J.; LIU, B.C.; CHEN, J.H.; JHA,V. The novel coronavirus 2019 epidemicand kidneys. Kidney International. Article in Press, 2020.
NG, D.L.; HOSANI, F.AL.; KEATING, M.K.; GERBER, S.I.; JONES, T.L.; METCALFE, M.G.; TONG, S.;TAO, Y.; ALAMI, N.N.; HAYNES, L.M.; MUTEI, M.; ABDEL-WARETH, L.; UYEKI, T.M.;SWERDLOW, D.L.; BARAKAT, M.; ZAKI, S.R. Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates. Immunopatholo-gy and infectious diseases, v.186, n.3, p.652-658, 2016.
OSBORN, M.; LUCAS, S.; STEWART, R.; SWIFT, B.; YOUD, E. Autopsy practice relating to possible cases of COVID-19 (2019-nCov, novel corona-virus from China 2019/2020), London: The Royal College of Pathologists, 2020. Disponívelem: https://www.rcpath.org/uploads/assets/d5e28baf-5789-4b0f-acecfe370eee6223/fe8fa85a-f004-4a0c-81ee4b2b9cd12cbf/Briefing-on-COVID-19-autopsy-Feb-2020.pdf. Acessoem 21 de julho de 2020.
PAN, L.; MU, M.; YANG, P.; SUN, Y.; WANG, R.; YAN, J.; LI, P.; HU, B.; WANG, J.; HU, C.;Y.; JIN, Y.; NIU, X.; PING, R.; DU, Y.; LI, T.; XU, G.; HU, Q.; TU, L. Clinical characteristics of COVID-19 patients with digestive symp-toms in Hubei, China: a descriptive, cross sectional, multicenter study. American journal of gastroenterology, v.115, p.766–773, 2020..
POYIADJI, N.; SHAHIN, G.; NOUJAIM, D.; STONE, M.; PATEL, S.; GRIFFITH, B. COVID-19–associatedacutehemorrhagicnecrotizingencephalopathy: imagingfeatures. Radiolo-gy, v.296, p.119-120, 2020.
RECALCATI SS. Cutaneousmanifesta-tions in COVID-19: a first perspective. Journaloftheeuropeanacademyofder-matologyandvenereology, v.34, p.210–240, 2020. < DOI: 10.1111/jdv.16389>
SU, H.; YANG, M.; WAN, C.; YI, L.X.; TANG, F.; ZHU, H.Y.; YI, F.; YANG, H.C.; FOGO, A.B.; NIE, X.; ZHANG, C. Renal histopathologicalanalysisof 26 postmortemfindingsofpatientswith COVID-19 in China. Kidney Interna-tional, v.98, p.219–227, 2020. < doi:10.1016/j.kint.2020.04.003>
TIAN, S.; XIONG, Y.; LIU, H.; NIU, L.; GUO, J.; LIAO, M.; XIAO, S.Y. Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies. Modern Pathology, v.33, p.1007–1014, 2020.
XIAOHONG, Y.; TINGYUAN, L.; ZHICHENG, H.; YIFANG, P.; HUAWEN, L.; SHICANG, Y.; HUAMING, M.; LIHUA, W.; HUARONG, Z.; WENJUAN, F.; TAO, L.; FENG, L.; CONG, C.; HUALIANG, X.; HAITAO, G.; SHUANG, L.; DONGFANG, X.; YU, S.; QINGRUI, L.; XIA, H.; YONG, C.; XIZHAO, L.; WEI, T.; PENGFEI, P.; XUEQUAN, H.; YANQING, D.; XIUWU, B. Estudo-histopatológico de trêscasos de nova pneumonia por coronavírus (COVID-19) com múltiploslocais de punção. Chinese Journal of Pathology, v.49, p.03-15, 2020.
ZHE XU, LEI SHI, YIJIN WANG, JI-YUAN ZHANG, LEI HUANG, CHAO ZHANG, SHUHONG LIU, PENG ZHAO, HONGXIA LIU, LI ZHU, YANHONG TAI, CHANGQING BAI, TINGTING GAO,JINWEN SONG, PENG XIA, JINGHUI DONG, JING-MIN ZHAO, FU-SHENG WANG Pathological findings of COVID-19 as-sociated with acute respiratory distress syndrome. Lancet Respiratory Medicine v. 8, p. 420–422 2020. https://doi.org/10.1016/S2213-2600(20)30076-X
BAIG, A.M.; KHALEEQ, A.; ALI, U.; SYEDA, H. Evidence of the COVID-19 virus targeting the cns: tissue distribution, host−virus interaction, and proposed neu-rotropic mechanisms. ACS Chemichal Neuroscience, In Press, 2020.
BARRY ROCKX, THIJS KUIKEN, SANDER HERFST, THEO BESTEBROER, MART M. LAMERS, BAS B. OUDE MUNNINK, DENNIS DE MEULDER, GEERT VAN AMERONGEN, JUDITH VAN DEN BRAND, NISREEN M. A. OKBA, DEBBY SCHIPPER, PETER VAN RUN, LONNEKE LEIJTEN, REINA SIKKEMA, ERNST VERSCHOOR, BABS VERSTREPEN, WILLY BOGERS, JAN LANGERMANS, CHRISTIAN DROSTEN, MARTJE FENTENER VAN VLISSINGEN, RON FOUCHIER, RIK DE SWART, MARION KOOPMANS AND BART L. HAAGMANS . Comparative pathogene-sis of COVID-19, MERS, and SARS in a nonhuman primate model , Science v.368, p. 1012–1015, 2020. https://doi.org/10.1126/science.abc4776
BENJAMIN T BRADLEY, HEATHER MAIOLI, ROBERT JOHNSTON, IRFAN CHAUDHRY, SUSAN L FINK, HAODONG XU, BEHZAD NAJAFIAN, GAIL DEUTSCH, J MATTHEW LACY, TIMOTHY WIL-LIAMS, NICOLE YARID, DESIREE A MARSHALL Histopathology and ultra-structural findings of fatal COVID-19 infections in Washington State: a case series. Lancet. p 1 -13, 2020. https://doi.org/10.1016/S0140-6736(20)31305-2
CARVALHO, S.R.; AIRES, M.T.; JUNQUEIRA, J.C.F.; VALLADARES, M.A.; SOUZA, M.T.; FERNANDES, C.R. Doença inflamatória intestinal e COVID-19: Revisão. Residência pediátrica, v.10, p. 1-5, 2020.
CHANDRASHEKAR A, LIU J, MAR-TINOT AJ, MCMAHAN K, MERCA-DO NB, PETER L,. SARS-CoV-2 infec-tion protects against rechallenge in rhesus macaques. Science [Internet]. 2020. Available from: https://www.sciencemag.org/lookup/doi/10.1126/science.abc4776
NANSHAN CHEN, MIN ZHOU, XUANDONG, JIEMINGQU, FENG-YUN GONG, YANG HAN, YANG QIU, JINGLI WANG, YING LIU, YUAN WEI, JIA’ANXIA, TING YU, XINXIN ZHANG, LI ZHANG Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive studynovel coronavirus pneumonia in Wuhan, China:a descriptive study. Lancet v.13, p.395: 507 2020; https://doi.org/10.1016/S0140-6736(20)30211-7
HANLEY, B.; LUCAS, S.B.; YOUD, E.; SWIFT, B.; OSBORN, M. Autopsy in suspected COVID-19 cases. Journal of Clinical Pathology, v. 73, p. 239–242, 2020.
INCIARDI, R.M.; LUPI, L.; ZAC-CONE, G.; ITALIA, L.; RAFFO, M.; TOMASONI, D.; CANI, D.S.; CERINI, M.; FARINA, D.; GAVAZZI, E.; MAROLDI, R.; ADAMO, M.; AM-MIRATI, E.; SINAGRA, G.; LOM-BARDI, C.M.; METRA, M. Cardiac In-volvement in a Patient With Coronavirus Disease 2019 (COVID-19). JAMA car-diology, v.5, n.7, p.819-824.
JOHN M NICHOLLS, LEO L M POON, KAM C LEE, WAI F NG, SIK T LAI, CHUNG Y LEUNG, CHUNG M CHU, PAK K HUI, KONG L MAK, WILINA LIM, KIN W YAN, KWOK H CHAN, NGAI C TSANG, YI GUAN, KWOK Y YUEN, J S MALIK PEIRIS Lung pathology of fatal severe acute res-piratory syndrome. Lancet v. 361, p. 1773–1778. 2003.https://doi.org/10.1016/S0140-6736(20)30211-7
JOTHIMANI, D.; VENUGOPAL, R.; ABEDIN, M.F.; KALIAMOORTHY, I.; RELA, M. COVID-19 and Liver, Jour-nal of Hepatology,In Press, 2020,
CHEN, L.; DENG, C.; CHEN, X.; ZHANG, X.; CHEN, BO.; YU, H.; QIN, Y.; XIAO, K.; ZHANG, H.; SUN, X. Ocular manifestations and clinical charac-teristics of 534 cases of COVID-19 in China: A cross-sectional study. MedRxiv, In Press, 2020
MCGONAGLE, DENNIS, O’DONNELL, JAMES S, SHARIF, KASSEM, EMERY, PAUL, BRIDGEWOOD, CHARLES Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia. Lancet Rheumatology v-2: p. 437–445, 2020. https://doi.org/10.1016/S0140-6736(20)30211-7
NAICKER, S.; YANG, C.W.; HWANG, S.J.; LIU, B.C.; CHEN, J.H.; JHA,V. The novel coronavirus 2019 epidemicand kidneys. Kidney International. Article in Press, 2020.
NG, D.L.; HOSANI, F.AL.; KEATING, M.K.; GERBER, S.I.; JONES, T.L.; METCALFE, M.G.; TONG, S.;TAO, Y.; ALAMI, N.N.; HAYNES, L.M.; MUTEI, M.; ABDEL-WARETH, L.; UYEKI, T.M.;SWERDLOW, D.L.; BARAKAT, M.; ZAKI, S.R. Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates. Immunopatholo-gy and infectious diseases, v.186, n.3, p.652-658, 2016.
OSBORN, M.; LUCAS, S.; STEWART, R.; SWIFT, B.; YOUD, E. Autopsy practice relating to possible cases of COVID-19 (2019-nCov, novel corona-virus from China 2019/2020), London: The Royal College of Pathologists, 2020. Disponívelem: https://www.rcpath.org/uploads/assets/d5e28baf-5789-4b0f-acecfe370eee6223/fe8fa85a-f004-4a0c-81ee4b2b9cd12cbf/Briefing-on-COVID-19-autopsy-Feb-2020.pdf. Acessoem 21 de julho de 2020.
PAN, L.; MU, M.; YANG, P.; SUN, Y.; WANG, R.; YAN, J.; LI, P.; HU, B.; WANG, J.; HU, C.;Y.; JIN, Y.; NIU, X.; PING, R.; DU, Y.; LI, T.; XU, G.; HU, Q.; TU, L. Clinical characteristics of COVID-19 patients with digestive symp-toms in Hubei, China: a descriptive, cross sectional, multicenter study. American journal of gastroenterology, v.115, p.766–773, 2020.
POYIADJI, N.; SHAHIN, G.; NOUJAIM, D.; STONE, M.; PATEL, S.; GRIFFITH, B. COVID-19–associatedacutehemorrhagicnecrotizingencephalopathy: imagingfeatures. Radiolo-gy, v.296, p.119-120, 2020.
RECALCATI SS. Cutaneousmanifesta-tions in COVID-19: a first perspective. Journaloftheeuropeanacademyofder-matologyandvenereology, v.34, p.210–240, 2020. < DOI: 10.1111/jdv.16389>
SU, H.; YANG, M.; WAN, C.; YI, L.X.; TANG, F.; ZHU, H.Y.; YI, F.; YANG, H.C.; FOGO, A.B.; NIE, X.; ZHANG, C. Renal histopathologicalanalysisof 26 postmortemfindingsofpatientswith COVID-19 in China. Kidney Interna-tional, v.98, p.219–227, 2020. < doi:10.1016/j.kint.2020.04.003>
TIAN, S.; XIONG, Y.; LIU, H.; NIU, L.; GUO, J.; LIAO, M.; XIAO, S.Y. Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies. Modern Pathology, v.33, p.1007–1014, 2020.
XIAOHONG, Y.; TINGYUAN, L.; ZHICHENG, H.; YIFANG, P.; HUAWEN, L.; SHICANG, Y.; HUAMING, M.; LIHUA, W.; HUARONG, Z.; WENJUAN, F.; TAO, L.; FENG, L.; CONG, C.; HUALIANG, X.; HAITAO, G.; SHUANG, L.; DONGFANG, X.; YU, S.; QINGRUI, L.; XIA, H.; YONG, C.; XIZHAO, L.; WEI, T.; PENGFEI, P.; XUEQUAN, H.; YANQING, D.; XIUWU, B. Estudo-histopatológico de trêscasos de nova pneumonia por coronavírus (COVID-19) com múltiploslocais de punção. Chinese Journal of Pathology, v.49, p.03-15, 2020.
ZHE XU, LEI SHI, YIJIN WANG, JI-YUAN ZHANG, LEI HUANG, CHAO ZHANG, SHUHONG LIU, PENG ZHAO, HONGXIA LIU, LI ZHU, YANHONG TAI, CHANGQING BAI, TINGTING GAO,JINWEN SONG, PENG XIA, JINGHUI DONG, JING-MIN ZHAO, FU-SHENG WANG Pathological findings of COVID-19 as-sociated with acute respiratory distress syndrome. Lancet Respiratory Medicine v. 8, p. 420–422 2020. https://doi.org/10.1016/S2213-2600(20)30076-X
Publicado
2020-08-28
Como Citar
Evangelista Bezerril, J., Machado, J. P., Albino Silva, S., & Tatiana Granja-Salcedo, Y. (2020). MACROSCOPIC AND MICROSCOPIC INJURIES OF PATIENTS AFFECT-ED BY COVID-19. Revista De Ciência Veterinária E Saúde Pública, 7(1), 054-061. https://doi.org/10.4025/revcivet.v7i1.55500
Seção
Artigos Originais
Declaro que o presente artigo é original, não tendo sido submetido à publicação em qualquer outro periódico nacional ou internacional, quer seja em parte ou em sua totalidade. Declaro, ainda, que uma vez publicado na revista Arquivo de Medicina veterinária e Saúde Pública da UEM, editada pela Universidade Estadual de Maringá, o mesmo jamais será submetido por mim ou por qualquer um dos demais co-autores a qualquer outro periódico. Através deste instrumento, em meu nome e em nome dos demais co-autores, porventura existentes, cedo os direitos autorais do referido artigo à Universidade Estadual de Maringá e declaro estar ciente de que a não observância deste compromisso submeterá o infrator a sanções e penas previstas na Lei de Proteção de Direitos Autorias (Nº9609, de 19/02/98).
