Evaluation of the tickcide, genotoxic, and mutagenic effects of the Ruta graveolens L. (Rutaceae)

Alessandra Vargas de Carvalho, Irina Lübeck, Mariana Balhego da Rocha, Camila Martins Güez, Michel Mansur Machado, Luís Flávio Souza de Oliveira

Resumo


Current analysis investigated the tickcide effects of the aqueous extract and chloroform fractions of Ruta graveolens L. (rue) on engorged females of Rhipicephalus microplus, as well as their genotoxic and mutagenic effects on human leukocytes. The best tickcide activity (non-dependent dose) and genotoxic / mutagenic effects (dependent-dose) were observed on exposure to chloroform fractions. Results suggest that extract fractions of R. graveolens L are efficient against R. microplus, although the fraction and the tested concentrations show genotoxic and mutagenic potential for human leukocytes.



 


Palavras-chave


acaricide; genotoxicity; rue.

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DOI: http://dx.doi.org/10.4025/actascibiolsci.v37i4.27576





ISSN 1679-9283 (impresso) e ISSN 1807-863X (on-line) e-mail: actabiol@uem.br

 

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