<b>Assessment of the healing activity of jucá pods [<i>Libidibia ferrea</i> (Mart. ex Tul.) L. P. Queiroz] in cutaneous lesions of rats

Autores

  • Frascisca Gomes Carvalho Faculdade de Saúde, Ciencias Humanas e Tecnológicas do Piauí­
  • João Paulo da Silva Sampaio Faculdade de Saúde, Ciencias Humanas e Tecnológicas do Piauí­
  • Maurycio Macedo dos Santos Araújo Faculdade de Saúde, Ciencias Humanas e Tecnológicas do Piauí­
  • Lucielma Salmito Soares Pinto Faculdade de Saúde, Ciencias Humanas e Tecnológicas do Piauí­
  • Antônio José Rocha Universidade Federal do Ceará

DOI:

https://doi.org/10.4025/actascitechnol.v38i2.28570

Palavras-chave:

medicinal plants, wound healing, healing activity

Resumo

The study aimed to evaluate the healing activity of the powdered pod of L. ferrea in cutaneous wound healing in preclinical test in rats. Eighteen rats were divided into two groups: the positive control group (PCG) treated with Kollagenase® and the experimental group (EG) treated with an ointment prepared with the powder of Libidibia ferrea. The lesions were clinically evaluated on 0 - 21st days, when histopathological analysis was also performed. In this study, the clinical analysis showed that although the rate of contraction of the lesions in EG was lower than in PCG, there was significant reduction in the wound of the group treated with ointment obtained from the powder of L. ferrea. Furthermore, the morphometric data showed that from the 3rd to 21st day after operation, the EG presented significant reduction in the rate of contraction of the skin lesions. Histological analysis revealed that the clinical and histological parameters of EG were similar to PCG. Although the biological activity of the powder remains unclarified, our results clearly showed the wound healing with the use of the powder of the pod of Libidibia ferrea in skin lesions. These finds provide subsidies for a similar research.

 

 

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Biografia do Autor

Frascisca Gomes Carvalho, Faculdade de Saúde, Ciencias Humanas e Tecnológicas do Piauí­

Departamento de bioquí­mica e Biologia Molecular

biologia molecular e genética molecular

João Paulo da Silva Sampaio, Faculdade de Saúde, Ciencias Humanas e Tecnológicas do Piauí­

Departamento de Farmacologia e Fisiologia, Faculdade de Saúde Ciencias Humanas e Tecnológicas do Piauí­ - NOVAFAPI, Rua Vitorino Orthiges Fernandes, nº 6123, Bairro do Uruguai, CEP: 64057-100, Teresina - Brasil.

Maurycio Macedo dos Santos Araújo, Faculdade de Saúde, Ciencias Humanas e Tecnológicas do Piauí­

Departamento de Farmacologia e Fisiologia, Faculdade de Saúde Ciencias Humanas e Tecnológicas do Piauí­ - NOVAFAPI, Rua Vitorino Orthiges Fernandes, nº 6123, Bairro do Uruguai, CEP: 64057-100, Teresina - Brasil.

Lucielma Salmito Soares Pinto, Faculdade de Saúde, Ciencias Humanas e Tecnológicas do Piauí­

Departamento de Farmacologia e Fisiologia, Faculdade de Saúde Ciencias Humanas e Tecnológicas do Piauí­ - NOVAFAPI, Rua Vitorino Orthiges Fernandes, nº 6123, Bairro do Uruguai, CEP: 64057-100, Teresina - Brasil.

Antônio José Rocha, Universidade Federal do Ceará

Departamento de Bioquí­mica e Biologia Molecular-Universidade Federal do Ceará-UFC - Avenida Humberto Monte s/n - Pici - Fortaleza - Brasil

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Publicado

2016-04-01

Como Citar

Carvalho, F. G., Sampaio, J. P. da S., Araújo, M. M. dos S., Pinto, L. S. S., & Rocha, A. J. (2016). <b>Assessment of the healing activity of jucá pods [<i>Libidibia ferrea</i> (Mart. ex Tul.) L. P. Queiroz] in cutaneous lesions of rats. Acta Scientiarum. Technology, 38(2), 137–143. https://doi.org/10.4025/actascitechnol.v38i2.28570

Edição

Seção

Biotecnologia