<b>Morphological study of splenic megakaryocytopoiesis in White New Zealand rabbits in the end of gestation and postnatal period</b> - DOI: 10.4025/actascianimsci.v25i1.2126

Abstract

Splenic megakaryocytopoiesis was studied in White New Zealand rabbits in the fetal and postnatal phase. The spleen was collected at the 28^th fetal day and at 4^th, 8^th, 12^th, 28^th, 56^th and 84^th days after birth. Morphologically, the megakaryocytic cells presented cytoplasm scarce to abundant, lightly basophilc to acidophilic, with large nucleus, reddish and irregular and variable amounts of chromatin loose to dense; the visible number of nucleoli varied depending on the chromatin pattern. It was evidenced megakaryocytopoietic activity and sequence all over the period of the study, by the presence of mature cells, in the 28^th day of fetal life and in the 84^th day of postnatal, presupposing a subsequent platelets production. It was individualized, sequentially, by megakaryoblast, promegakaryocyte, caryokinetic megakaryocyte, megakaryocite and metamegakaryocyte. We conclude that splenic megakaryocytopoiesis in rabbits produced platelets by presence of stimulator environment of hemocytopoiesis, or more specifically, by inductor microenvironment of megakaryocytopoiesis and thrombocytopoiesis.