Barrows and gilts respond differently as experimental models for Escherichia coli challenge during the nursery phase

Ana Clara Rodrigues de  Oliveira; Bruno Braga  Carnino; Eduarda Buck Bernardes  Guimarães; Laya Kanan Silva  Alves; Tarik Mohallem Pereira  Lima; Allan Paul Schinckel; Cesar Augusto Pospissil  Garbossa

doi:10.4025/actascianimsci.v47i1.71652

Ana Clara Rodrigues de Oliveira Universidade de São Paulo https://orcid.org/0000-0003-3908-6107
Bruno Braga Carnino Universidade de São Paulo https://orcid.org/0000-0001-8697-6247
Eduarda Buck Bernardes Guimarães Universidade de São Paulo https://orcid.org/0000-0002-1754-9759
Laya Kanan Silva Alves Universidade de São Paulo https://orcid.org/0000-0002-9534-6121
Tarik Mohallem Pereira Lima Universidade de São Paulo https://orcid.org/0009-0002-5051-5590
Allan Paul Schinckel Purdue University https://orcid.org/0000-0002-8614-7198
Cesar Augusto Pospissil Garbossa Universidade de São Paulo https://orcid.org/0000-0003-3244-7184

DOI: https://doi.org/10.4025/actascianimsci.v47i1.71652

Keywords: health; disease challenge model; swine.

Abstract

The objectives of this study were to evaluate the effect of Escherichia coli (E. coli) F4 challenge in nursery piglets, and to develop an experimental model to be used in research. Ninety-six weaned piglets were divided in a 2 x 2 factorial design consisting of E. coli challenge (challenged or not challenged) and sex (barrows or gilts). Pig growth performance, fecal score, blood count, intestinal morphometry, and cecal content (microbiological and short-chain fatty acid analysis) data were collected and analyzed. Pigs in the non-challenged treatment had 6% greater average daily gain during day 8-28 (the period in which the health challenge was administered) and 1.2% greater average daily feed intake in over the entire experiment, when compared to challenged pigs. Gilts in the non-challenged group had a higher villus: crypt ratio when compared to piglets in the challenged group. These findings indicate that the pathogen challenge using Escherichia coli F4 strains, especially in gilts, proved to be an effective method to reproduce commercial health challenges in the first two weeks postweaning and may be used in experimental models.

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Barrows and gilts respond differently as experimental models for Escherichia coli challenge during the nursery phase

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