Effect of the chronic administration of caffeine on adipose mass and lipid profile of Wistar rats - doi: 10.4025/actascibiolsci.v35i2.11085

Priscila Nakagawa; Maria Montserrat Diaz Pedrosa

doi:10.4025/actascibiolsci.v35i2.11085

Effect of the chronic administration of caffeine on adipose mass and lipid profile of Wistar rats - doi: 10.4025/actascibiolsci.v35i2.11085

Priscila Nakagawa Universidade Estadual de Maringá
Maria Montserrat Diaz Pedrosa Universidade Estadual de Maringá

DOI: https://doi.org/10.4025/actascibiolsci.v35i2.11085

Abstract

This work aimed at verifying the effect of the chronic ingestion of caffeine on body weight and adiposity of Wistar rats. Sixteen male Wistar rats weighting on average 240 g were divided into two groups, one control and the other caffeine-treated (5 mg kg-1, orally) for five weeks. At the end, the groups were evaluated for their differences in body weight; weight of the periepididymal, retroperitoneal, subcutaneous and mesenteric fat pads; size of the retroperitoneal adipocytes; liver and heart weight; glycemia and plasma lipids. Statistically significant differences were observed in adipocyte size and total serum cholesterol, while the results for the other parameters were not statistically different. Therefore, this study showed that, using an oral dose of caffeine within acceptable (non toxic) limits, it is possible to reduce the size of adipocytes of non-obese Wistar rats, as well as to reduce the serum cholesterol levels, even in the absence of physical activity or other active compounds.

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Author Biographies

Priscila Nakagawa, Universidade Estadual de Maringá

graduada em nutrição pelo Cesumar; especialista em fisiologia humana pela UEM

Maria Montserrat Diaz Pedrosa, Universidade Estadual de Maringá

Araduação em Ciências Biológicas pela Universidade Estadual de Maringá (1991), mestrado e doutorado em Ciências Biológicas (Biologia Celular) pela Universidade Estadual de Maringá (1999 e 2002) . Atualmente é professora adjunta da Universidade Estadual de Maringá. Tem experiência na área de Fisiologia, com ênfase em Fisiologia de Órgãos e Sistemas, atuando principalmente nos seguintes temas: neurônios mioentéricos, diabetes, restrição alimentar. Docente de biofísica, fisiologia humana e fisiologia animal. Coordenadora, orientadora e professora do curso de especialização em fisiologia humana da UEM. Currículo Lattes

Published

2012-12-20

How to Cite

Nakagawa, P., & Pedrosa, M. M. D. (2012). Effect of the chronic administration of caffeine on adipose mass and lipid profile of Wistar rats - doi: 10.4025/actascibiolsci.v35i2.11085. Acta Scientiarum. Biological Sciences, 35(2), 293-298. https://doi.org/10.4025/actascibiolsci.v35i2.11085

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Issue

Vol 35 No 2 (2013)

Section

Animal Morphology & Physiology

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