<b>Phytochemical analysis and modulation in aminoglycosides antibiotics activity by <i>Lantana camara</i> L.

Erlânio Oliveira de Sousa; Fabíola Fernandez Galvão Rodrigues; Adriana Rolim Campos; José Galberto Martins da Costa

doi:10.4025/actascibiolsci.v37i2.22877

Erlânio Oliveira de Sousa Universidade Estadual do Ceará; Universidade Regional do Cariri
Fabíola Fernandez Galvão Rodrigues Universidade Estadual do Ceará; Universidade Regional do Cariri
Adriana Rolim Campos Universidade de Fortaleza
José Galberto Martins da Costa Universidade Estadual do Ceará; Universidade Regional do Cariri

DOI: https://doi.org/10.4025/actascibiolsci.v37i2.22877

Keywords: Lantana camara L., antibacterial activity, aminoglycosides, synergism.

Abstract

Several plants have been evaluated not only for alone antimicrobial activity, but as resistance-modifying agent. This work is the first on the modulation of antibiotic activity by Lantana camara L. extracts against multiresistant strains of Escherichia coli and Staphylococcus aureus. The antibacterial activities of leaf and root ethanol extracts alone or in association with aminoglycosides were determined against bacterial strains by a microdilution test. The minimum inhibitory concentration (MIC) of the extracts was compared with of the aminoglycosides. Phytochemical prospection revealed the presence of quinones, steroids, flavonoids, saponins, tannins, triterpenoids and alkaloids. The results showed antibacterial activities of the extracts and synergistic effects combined with aminoglycosides. The most expressive effects were obtained with root extract but gentamicin or but neomycin against E. coli with MICs decreased (312 to 5 µg mL^-1). The data from this study are indicative of the antibacterial activity of L. camara’s extracts and its potential in modifying the resistance of aminoglycosides analyzed.

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Author Biographies

Fabíola Fernandez Galvão Rodrigues, Universidade Estadual do Ceará; Universidade Regional do Cariri

¹Northeast Network on Biotechnology, State University of Ceará, 60811-905, Fortaleza - CE, Brazil. ²Molecular Bioprospection Postgraduation Program, Laboratory of Natural Products Research, Regional University of Cariri, 63105 - 000, Crato, CE, Brazil. Author for correspondence.

Adriana Rolim Campos, Universidade de Fortaleza

Northeast Network on Biotechnology, State University of Ceará, 60811-905, Fortaleza - CE, Brazil. -�[ s-�U ��V anguage: AR-SA;mso-bidi-language:AR-SA'>, State University of Ceará, 60811-905, Fortaleza - CE, Brazil. ²Molecular Bioprospection Postgraduation Program, Laboratory of Natural Products Research, Regional University of Cariri, 63105 - 000, Crato, CE, Brazil. Author for correspondence.

José Galberto Martins da Costa, Universidade Estadual do Ceará; Universidade Regional do Cariri

¹Northeast Network on Biotechnology, State University of Ceará, 60811-905, Fortaleza - CE, Brazil. ²Molecular Bioprospection Postgraduation Program, Laboratory of Natural Products Research, Regional University of Cariri, 63105 - 000, Crato, CE, Brazil. Author for correspondence.