Instabilidade mitótica e meiótica produzida por um supressor informacional em Aspergillus nidulans

Melissa Gracite de Melo Franzoni; Marialba Avezum Alves Castro Prado

doi:10.4025/actascibiolsci.v22i0.2810

Mitotic and meiotic instability produced by an informational suppressor in Aspergillus nidulans

Melissa Gracite de Melo Franzoni UEM
Marialba Avezum Alves Castro Prado UEM

DOI: https://doi.org/10.4025/actascibiolsci.v22i0.2810

Abstract

The genetic instability induced by the informational suppressor suO1 in Aspergillus nidulans is described. suO1 was selected through the properties of coreversion of several physiologically unrelated mutations. This mutation decreased the conidia and ascospores viability of the suppressor strains. These strains were unstable at mitosis and meiosis, producing improved derivatives, phenotypically different from the original strains. Meiotic crosses, heterozygous for the suppressor mutation, produced barren cleistothecia. suO1 was unstable in the restoration of the genetic alterations present in the genome of M-15 mutant, producing more than 25.0% unsuppressed progeny in heterozygous crosses for auxotrophyc mutations (for instance, su, ribo x su⁺, ribo⁺) . Our results suggested that suO1 altered the fidelity of the translation process, inducing mistranslation of normal and mutant mRNAs

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Author Biography

Marialba Avezum Alves Castro Prado, UEM

possui graduação em Bacharelado Em Ciências Biológicas pela Organização Educacional Barão de Mauá (1980), mestrado em Ciências Biológicas (Genética) pela Universidade de São Paulo (1985) e doutorado em Ciências Biológicas (Genética) pela Universidade de São Paulo (1992). Atualmente é professor associado - nível c da Universidade Estadual de Maringá. Tem experiência na área de Genética, com ênfase em Controle da Expressão Gênica, atuando principalmente nos seguintes temas: Parassexualidade em fungos filamentosos, Genética do desenvolvimento, Controle do crossing-over e Genotoxicidade (recombinação mitótica) de substâncias químicas Currículo Lattes

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Published

2008-05-09

How to Cite

Franzoni, M. G. de M., & Prado, M. A. A. C. (2008). Mitotic and meiotic instability produced by an informational suppressor in Aspergillus nidulans. Acta Scientiarum. Biological Sciences, 22, 263-268. https://doi.org/10.4025/actascibiolsci.v22i0.2810

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Issue

Vol 22 (2000)

Section

Biology Sciences

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