<b>Metabolic modeling and comparative biochemistry in glyoxylate cycle

  • Itamar Luís Gonçalves Universidade Federal do Rio Grande do Sul
  • Albanin Aparecida Mielniczki-Pereira Universidade Regional Integrada do Alto Uruguai e das Missões
  • Ana Claudia Piovezan Borges Universidade Regional Integrada do Alto Uruguai e das Missões
  • Alice Teresa Valduga Universidade Regional Integrada do Alto Uruguai e das Missões
Palavras-chave: catabolism, energy efficiency, acetyl-CoA oxidation

Resumo

Glyoxylate cycle in fatty acid catabolism enhances net production of oxaloacetate, a substrate for gluconeogenesis, in certain bacteria, invertebrates and oilseed in the growth stage. A theoretical model was developed to calculate ATP amount produced in each step of the catabolic pathway, taking into account the fatty acid’s hydrocarbon chain size. Results showed a decrease in energy efficiency in glyoxylate cycle when compared to animal metabolism. Although the glyoxylate cycle provides evolutionary adaptations, it determines a smaller amount of energy produced per carbon atom when compared to animal catabolism of fatty acids.

 

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Publicado
2016-07-21
Como Citar
Gonçalves, I. L., Mielniczki-Pereira, A. A., Piovezan Borges, A. C., & Valduga, A. T. (2016). <b&gt;Metabolic modeling and comparative biochemistry in glyoxylate cycle. Acta Scientiarum. Biological Sciences, 38(1), 1-6. https://doi.org/10.4025/actascibiolsci.v38i1.24597
Seção
Bioquímica

 

0.6
2019CiteScore
 
 
31st percentile
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0.6
2019CiteScore
 
 
31st percentile
Powered by  Scopus