Hypercholesterolemia and hepatic steatosis in mice fed on low-cost high-fat diet - doi: 10.4025/actascihealthsci.v35i1.10871

Autores

  • Diego Castro Musial Faculdade Integrado de Campo Mourão Autor
  • Tânia Cristina Alexandrino Becker Faculdade Integrado de Campo Mourão Autor
  • Aline Paula Isolani Laboratório de Análises Clínicas Santa Cecília Autor
  • Lívia Bracht Universidade Tecnológica Federal do Paraná Autor
  • Ana Carla Broetto Biazon Faculdade Integrado de Campo Mourão Autor

DOI:

https://doi.org/10.4025/actascihealthsci.v35i1.10871

Palavras-chave:

hypercholesterolemia, fatty liver, high-fat diet

Resumo

To verify whether high-fat diet prepared from commercial diet plus chocolate, roasted peanuts and corn cookies induces hypercholesterolemia in mice and whether there is any hepatic involvement in this type of animal testing. Swiss mice received a high-fat diet for 15 and 30 days; plasma cholesterol, triglycerides and glucose rates were determined. Hepatic impairment was evaluated by histopathological analysis. Cholesterol levels increased 43% in animals treated with high-fat diet for 30 days. Further, histopathological analysis revealed that treatment of animals for 15 and 30 days produced hepatic steatosis and steatohepatitis, respectively. Experimental model is suitable for assessing the action of anti-hypercholesterolemia and the treatment of steatohepatitis.

 

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Publicado

2012-10-31

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Ciências da Saúde

Como Citar

Hypercholesterolemia and hepatic steatosis in mice fed on low-cost high-fat diet - doi: 10.4025/actascihealthsci.v35i1.10871. (2012). Acta Scientiarum. Health Sciences, 35(1), 23-27. https://doi.org/10.4025/actascihealthsci.v35i1.10871

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