Hypercholesterolemia and hepatic steatosis in mice fed on low-cost high-fat diet - doi: 10.4025/actascihealthsci.v35i1.10871

Diego Castro Musial; Tânia Cristina Alexandrino Becker; Aline Paula Isolani; Lívia Bracht; Ana Carla Broetto Biazon

doi:10.4025/actascihealthsci.v35i1.10871

Hypercholesterolemia and hepatic steatosis in mice fed on low-cost high-fat diet - doi: 10.4025/actascihealthsci.v35i1.10871

Authors

Diego Castro Musial Faculdade Integrado de Campo Mourão Author
Tânia Cristina Alexandrino Becker Faculdade Integrado de Campo Mourão Author
Aline Paula Isolani Laboratório de Análises Clínicas Santa Cecília Author
Lívia Bracht Universidade Tecnológica Federal do Paraná Author
Ana Carla Broetto Biazon Faculdade Integrado de Campo Mourão Author

DOI:

https://doi.org/10.4025/actascihealthsci.v35i1.10871

Keywords:

hypercholesterolemia, fatty liver, high-fat diet

Abstract

To verify whether high-fat diet prepared from commercial diet plus chocolate, roasted peanuts and corn cookies induces hypercholesterolemia in mice and whether there is any hepatic involvement in this type of animal testing. Swiss mice received a high-fat diet for 15 and 30 days; plasma cholesterol, triglycerides and glucose rates were determined. Hepatic impairment was evaluated by histopathological analysis. Cholesterol levels increased 43% in animals treated with high-fat diet for 30 days. Further, histopathological analysis revealed that treatment of animals for 15 and 30 days produced hepatic steatosis and steatohepatitis, respectively. Experimental model is suitable for assessing the action of anti-hypercholesterolemia and the treatment of steatohepatitis.

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Published

2012-10-31

Issue

Vol. 35 No. 1 (2013)

Section

Health Sciences

License

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How to Cite

Musial, D. C., Becker, T. C. A., Isolani, A. P., Bracht, L., & Biazon, A. C. B. (2012). Hypercholesterolemia and hepatic steatosis in mice fed on low-cost high-fat diet - doi: 10.4025/actascihealthsci.v35i1.10871. Acta Scientiarum. Health Sciences, 35(1), 23-27. https://doi.org/10.4025/actascihealthsci.v35i1.10871