Obtenção de comprimidos contendo cálcio de conchas de ostras: pré-formulação e liodisponibilidade comparativa - DOI: 10.4025/actascihealthsci.v28i1.1116

Lívio César Cunha Nunes; Aíla Karla Mota Santana; José Lamartine Soares Sobrinho; Mônica Felts de La Roca; Ednaldo Queiroga de Lima; Pedro José Rolim Neto

doi:10.4025/actascihealthsci.v28i1.1116

Obtaining tablets with calcium from oyster shells: preformulation and comparative lyoavailability - DOI: 10.4025/actascihealthsci.v28i1.1116

Authors

Lívio César Cunha Nunes UFPE Author
Aíla Karla Mota Santana UFPE Author
José Lamartine Soares Sobrinho UFPE Author
Mônica Felts de La Roca UFPE Author
Ednaldo Queiroga de Lima UFPE Author
Pedro José Rolim Neto UFPE Author

DOI:

https://doi.org/10.4025/actascihealthsci.v28i1.1116

Keywords:

osteoporose, cálcio, pó de concha de ostra, comprimidos

Abstract

Osteoporosis is a disease that affects a significant number of people in the world, particularly in developing countries. In this context, the powder of oyster shells, found to be a calcium source, emerges as one opportunity to use the natural resources from the Brazilian coast region for alimentary supplementation. This study proposes the use of this natural source of calcium, incorporated in tablets. The study was developed in two parts. The first was concerned with optimizing the raw material from oyster shells, from the selection process until the transformation of de oyster shell into dust; and with the physicochemical evaluation and preformulation of this dust. The second part consisted of obtaining tablets, from the development until the comparative evaluation of lyoavailability. The studies on preformulation and factorial planning of the excipients (binging agent, levigating agent and disintegrants) have made possible to obtain tables with a similar lyoavailability, in terms of economy and performance, to the medicine reference Os-cal^®

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Author Biography

Pedro José Rolim Neto, UFPE

Graduado em Farmácia pela Universidade Federal de Pernambuco (UFPE) em 1982, obtendo habilitação em Indústria em 1983 pela mesma Universidade. Mestre em Ciências Farmacêuticas, em 1988, pela UFPE. Obteve o título de Especialista em Farmácia Industrial, (1989), Diploma de Estudos Aprofundados (1990) e o Doutorado (de 1988 a 1992) pela Universidade de Montpellier I, na França. Participou do curso promovido pela Food and Drug Administration (FDA) sobre Boas Práticas de Fabricação para Produtos Farmacêuticos, na Universidade de Puerto Rico, em San Juan em 2001. Desenvolve pesquisa para diversas Indústrias Farmacêuticas a 18 anos. Atualmente é professor adjunto da UFPE, Coordenador do Laboratório de Tecnologia dos Medicamentos (LTM) e Coordenador do Programa de Pós-Graduação em Ciências Farmacêuticas da UFPE. Atua na área de Tecnologia Farmacêutica, obtenção de formas farmacêuticas classicas e sistemas de vetorização de fármacos de origem natural e sintética Currículo Lattes

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Published

2008-03-13

Issue

Vol. 28 No. 1 (2006)

Section

Pharmacy

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How to Cite

Obtaining tablets with calcium from oyster shells: preformulation and comparative lyoavailability - DOI: 10.4025/actascihealthsci.v28i1.1116. (2008). Acta Scientiarum. Health Sciences, 28(1), 49-55. https://doi.org/10.4025/actascihealthsci.v28i1.1116