<b>Treatments and supportive therapies for oral manifestations of chronic graft-versus-host disease

  • Rafaella Gabriel Maiolino Universidade Estadual de Maringá
  • Amanda Lury Yamashita Universidade Estadual de Maringá
  • Lilian Cristina Vessoni Iwaki Universidade Estadual de Maringá
  • Liogi Iwaki Filho Universidade Estadual de Maringá
  • Wilton Mitsunari Takeshita Universidade Estadual de Maringá
  • Mariliani Chicarelli Universidade Estadual de Maringá

Resumo

The aim of this study was to conduct a systematic review of treatments and therapies for oral manifestations of chronic graft-versus-host disease, aiming at improving patients’ quality of life and mainly the reduction of mortality caused by graft-versus-host disease. A systematic review was carried out by two evaluators, a Dentistry professor and an undergraduate student. A selection of open-access full-text online articles, carried out on PubMed, GoPubmed, NLM Gateway, LILACS, BIREME, SciELO, IBECS, and Web of Science. The survey was completed in July 2012. Of the 1147 studies found, 52 fit the selection criteria. Patients (n = 2130) received different treatment regimens, either systemic or topical. Drugs for systemic therapy were divided into those with action on the inhibition of proliferation and/or release of T and B cells, with action on inflammatory disorders, and of immunomodulatory effect. Topical drugs were divided into their pattern of mucosal absorption and their ability to act on tissue growth factors. The analysis of articles concluded that the most used systemic drugs were Methylprednisolone and corticosteroids, and Tacrolimus and topical Cyclosporine for topical and local therapy.

 

 

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Biografia do Autor

Rafaella Gabriel Maiolino, Universidade Estadual de Maringá
Mestrando em Odontologia Integrada da Universidade Estadual de Maringá
Amanda Lury Yamashita, Universidade Estadual de Maringá
DDS, MA applicant at Universidade Estadual de Maringá.
Lilian Cristina Vessoni Iwaki, Universidade Estadual de Maringá
PhD in Oral Radiology, Professor of Stomatology and Oral Radiology, Department of Dentistry, State University of Maringá.
Liogi Iwaki Filho, Universidade Estadual de Maringá

PhD in Oral Diagnostic. Professor of Oral-Maxillofacial Surgery at Universidade Estadual de Maringá.

Wilton Mitsunari Takeshita, Universidade Estadual de Maringá
DDS, PhD in Oral Radiology, Professor of Oral Diagnostic and Oral Radiology at Federal University of Sergipe.
Mariliani Chicarelli, Universidade Estadual de Maringá
DDS, PhD in Oral Radiology, Professor of Stomatology and Oral Radiology at State University of Maringá.
Publicado
2016-06-08
Como Citar
Maiolino, R. G., Yamashita, A. L., Iwaki, L. C. V., Iwaki Filho, L., Takeshita, W. M., & Chicarelli, M. (2016). <b&gt;Treatments and supportive therapies for oral manifestations of chronic graft-versus-host disease. Acta Scientiarum. Health Sciences, 38(1), 111-121. https://doi.org/10.4025/actascihealthsci.v38i1.23894
Seção
Odontologia

0.3
2019CiteScore
 
 
8th percentile
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0.3
2019CiteScore
 
 
8th percentile
Powered by  Scopus