Development of AAS 500 mg tablets influenced by direct compression (CD) process
DOI:
https://doi.org/10.4025/actascihealthsci.v24i0.2479Keywords:
Amido 1500®, Ãcido Acetil Salicílico, comprimidos, compressão diretaAbstract
The present work aims to show the technologic viability in the development of AAS 500 mg tablets using direct compression (CD) process. We employed Starch 1500® as excipient to develop the formulations, trying to investigate its compression, disintegration, aggregation and lubrication properties. Technologic, physical and chemical essays were performed using methodologies anticipated in pharmacology. Results demonstrated that the powder mix showed characteristics of free flux and good compression qualities very important for the excipients of direct compression in the market. Starch 1500® interfered in the disintegration time. The formulation with 6,35% of Starch 1500® proposed in this work obtained a highest proximity between the products in the Brazilian marketDownloads
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Published
2008-04-24
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Health Sciences
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How to Cite
Development of AAS 500 mg tablets influenced by direct compression (CD) process. (2008). Acta Scientiarum. Health Sciences, 24, 649-655. https://doi.org/10.4025/actascihealthsci.v24i0.2479
