Estudo da associação Li2CO3 e adoçante não-calórico, C7H5NO3S, em células de medula óssea de camundongos

Juida de Deus Palma Contar; Luciana Oliveira dos Santos; Simone Busko Valim; Terezinha Aparecida Guedes

doi:10.4025/actascihealthsci.v21i0.4454

A study of Li₂CO₃ and C₇H₅NO₃S noncaloric sweetener association in mice bone marrow cells

Authors

Juida de Deus Palma Contar UEM Author
Luciana Oliveira dos Santos UEM Author
Simone Busko Valim UEM Author
Terezinha Aparecida Guedes UEM Author

DOI:

https://doi.org/10.4025/actascihealthsci.v21i0.4454

Keywords:

camundongos, lítio, sacarina, células de medula óssea, micronúcleo

Abstract

This article presents the results of a research, project designed to evaluate the association of lithium carbonate and noncaloric sweetener in laboratory Swiss albino female mice, in a study phase using saccharin (Sc). The aim of this study was to evaluate significant differences as indicators of mutagenesis in treated mice groups. In nine tables, the micronucleus (MN) rate calculated in polychromatic erythrocytes (PCE) and normochromatic erythrocytes (NCE) was assessed. The animals were lithium orally treated for 10 days at the concentration of 100mg/kg or lithium treated in association with saccharin at the same concentration. The results were compared to groups treated with cyclophosphamide (Ci) (+) and water (-) - controls. Variance statistical analysis followed by Tukey’s test showed significant differences (p < 0.05) as for the mean MN rates in PCE and NCE and as for sum total with F= 16.57, 9.67 and F = 15.63 respectively. The by two comparison was analyzed by Student’s “t” test and significant differences were observed for Ci (+) group only. Considering the methodology used in female mice and the statistical analysis employed no mutagenesis indication was found MN frequency in bone marrow cells for this species.

Downloads

Download data is not yet available.

Author Biography

Juida de Deus Palma Contar, UEM

Possui doutorado pela Universidade Federal de São Paulo (1985) . Atualmente é SOCIO da Soc. Brasileira Progresso Ciência - SP, pesquisadora da Soc. Brasileira Progresso Ciência - SP, PROFESSOR ADJUNTO da Universidade Estadual de Maringá, PROFESSOR- PESQUISADOR da Universidade Estadual de Maringá, PROFESSOR ADJUNTOIV da Universidade Estadual de Maringá, Integral com Dedicação Exclusiva da Universidade Estadual de Maringá e REVISORA CIENTIFICA da Universidade Estadual de Maringá. Tem experiência na área de Farmacologia , com ênfase em Neuropsicofarmacologia. Atuando principalmente nos seguintes temas: Comportamento, Ratos e Camundongos, Toxicologia, Psicofarmacologia Currículo Lattes

Downloads

PDF (Portuguese)

Published

2008-07-17

Issue

Vol. 21 (1999)

Section

Health Sciences

License

DECLARATION OF ORIGINALITY AND COPYRIGHTS

I Declare that current article is original and has not been submitted for publication, in part or in whole, to any other national or international journal.

The copyrights belong exclusively to the authors. Published content is licensed under Creative Commons Attribution 4.0 (CC BY 4.0) guidelines, which allows sharing (copy and distribution of the material in any medium or format) and adaptation (remix, transform, and build upon the material) for any purpose, even commercially, under the terms of attribution.

Read this link for further information on how to use CC BY 4.0 properly.

How to Cite

Contar, J. de D. P., Santos, L. O. dos, Valim, S. B., & Guedes, T. A. (2008). A study of Li2CO3 and C7H5NO3S noncaloric sweetener association in mice bone marrow cells. Acta Scientiarum. Health Sciences, 21, 403-408. https://doi.org/10.4025/actascihealthsci.v21i0.4454