Expressão de genes relacionados Ã  função adrenocortical no estado de caquexia neoplásica - DOI: 10.4025/actascihealthsci.v31i2.6759

Nicole de Angelis Scripes; Marcelo Abbá Macioszek; Larissa Danielle Bahls; Mateus Nóbrega Aoki; Maria Angélica Ehara Watanabe; Tânia Longo Mazzuco

doi:10.4025/actascihealthsci.v31i2.6759

Expression of genes related to the adrenocortical function in the neoplastic cachexia process- DOI: 10.4025/actascihealthsci.v31i2.6759

Authors

Nicole de Angelis Scripes UEL Author
Marcelo Abbá Macioszek UEL Author
Larissa Danielle Bahls UEL Author
Mateus Nóbrega Aoki UEL Author
Maria Angélica Ehara Watanabe UEL Author
Tânia Longo Mazzuco UEL Author

DOI:

https://doi.org/10.4025/actascihealthsci.v31i2.6759

Keywords:

adrenal glands, cachexia, corticotropin receptors, 3-hydroxysteroid dehydrogenases, translocator protein, steroidogenic acute regulatory protein

Abstract

The adrenal gland plays a crucial role in the neuroendocrine response, especially in situations where homeostasis is disturbed. In the neoplastic cachexia process, there is homeostasis impairment by nutritional and metabolic alterations of advanced-stage cancer, involving hypothalamus-pituitary-adrenal axis response. In this assignment, an experimental model of cachexia induced by Walker-256 tumor was performed in Wistar rats. Animals (n=4) were sacrificed 10 days after inoculation of tumor cells, and the adrenal glands were excised. The RNA was isolated for the study of gene expression related to the steroidogenesis control by semi-quantitative RT-PCR. Data analysis showed a significant reduced expression of MC2R (melancortin type 2 receptor), 3ßHSD I (3-beta-hydroxysteroid dehydrogenase type I) and TSPO (translocator protein) genes in animals with neoplastic cachexia (P=0.037, 0.0097 and 0.052, respectively), revealing adrenal cortex failure.

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Author Biography

Tânia Longo Mazzuco, UEL

Atualmente realiza um fellowship em endocrinologia clìnica e pesquisa, Universidade de Montréal, Canadá. Tem experiência na área de Medicina, com ênfase em Endocrinologia, atuando principalmente nos seguintes temas: adrenal, neuroendocrinologia, tumorigênese, farmacologia, fitoterápicos, câncer, biologia molecular. Currículo Lattes

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Published

2009-09-17

Issue

Vol. 31 No. 2 (2009)

Section

Medicine

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How to Cite

Expression of genes related to the adrenocortical function in the neoplastic cachexia process- DOI: 10.4025/actascihealthsci.v31i2.6759. (2009). Acta Scientiarum. Health Sciences, 31(2), 133-141. https://doi.org/10.4025/actascihealthsci.v31i2.6759