<b>Anxiolytic effect of spermine microinjected into the dorsal periaqueductal grey in rats</b> - DOI: 10.4025/actascihealthsci.v28i1.1113
Abstract
To investigate a possible effect of the spermine and its polyamins receptors in the dorsal periaqueductal grey (DPAG) in anxiety. Groups of rats received microinjections of spermine (2.5 nmol) into DPAG and were tested in the elevated plus-maze apparatus. Results indicated an overall significant increase in the percentage of entries and in the time spent in open arms. In another experiment the anxiolytic effect obtained after the microinjection of spermine (2.5 nmol) into DPAG was block by previous microinjection of polyamines antagonists, arcaine (4 nmol) or ifenprodil (5 nmol) into the same site. These results indicate that the spermine receptor interaction in the modulation of anxiety in rats exposed to the elevated plus-maze. Considering that polyamines are natural component of the brain, these results suggest that polyamine system within DPAG may play a role in aversion and anxietyDownloads
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Published
2008-03-13
How to Cite
Pereira da Cruz, J. G., & de Pádua Carobrez, A. (2008). <b>Anxiolytic effect of spermine microinjected into the dorsal periaqueductal grey in rats</b> - DOI: 10.4025/actascihealthsci.v28i1.1113. Acta Scientiarum. Health Sciences, 28(1), 43-47. https://doi.org/10.4025/actascihealthsci.v28i1.1113
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Section
Pharmacy
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