Estudo da toxidade do extrato de <em>Cordia salicifolia</em>

Abstract

This study was carried out to determine the acute toxicity of the whole Cordia salicifolia extract (LD₅₀) after oral and intraperitoneal administration in mice, and its effect on certain biochemical parameters in the plasma of rats after 90 days of administration. The oral LD₅₀ value of the extract was higher than 2000 mg/kg while the LD₅₀ by intraperitoneal injections was about 920 mg/kg. A daily oral administration of extracts at 20, 100, 200 and 400 mg/kg doses for 90 days did not cause significant changes in the body weight gain, organs weight or biochemical assays and hematology in the animals. The results showed that the administration of the extract for a prolonged period did not produce toxic effects in the animals