Avaliação das atividades hipoglicemiante e anti-hiperglicemiante do extrato hidroalcóolico das folhas da Averrhoa carambola L. (Oxalidaceae) em modelos experimentais de hiperglicemia

Simone Tomás Gonçalves; Silmara Baroni; Fernando Antonio Bersani-Amado; Juliano Luiz Sartoretto; Diógenes Aparício Garcia Cortez; Carlos Alexandre Molena Fernandes; Ciomar Aparecida Bersani-Amado; Roberto Kenji Nakamura Cuman

doi:10.4025/actascihealthsci.v27i1.1443

Evaluation of hypoglycemic and antihyperglycemic activities in hydroethanolic extract of <em>Averrhoa carambola</em> L. (Oxalidaceae) in experimental models of hyperglycemia

Simone Tomás Gonçalves UEM
Silmara Baroni UEM
Fernando Antonio Bersani-Amado UEM
Juliano Luiz Sartoretto UEM
Diógenes Aparício Garcia Cortez UEM
Carlos Alexandre Molena Fernandes UEM
Ciomar Aparecida Bersani-Amado UEM
Roberto Kenji Nakamura Cuman Farmácia/Análises Clínicas - UEM

DOI: https://doi.org/10.4025/actascihealthsci.v27i1.1443

Abstract

The hypoglycemic and antihyperglycemic activities of a hydroethanolic extract prepared from the leaves of Averrhoa carambola L. (Oxalidaceae) was evaluated in rats, through the experimental models of hyperglycemia: type 1 alloxan-induced diabetes, glucose intolerance and insulin resistance induced by dexamethasone and the chronic insulin resistance in obesity model induced by sodium monoglutamate. The hydroethanolic Averrhoa carambola extract at a dosage of 800 mg/Kg body weight did not exhibit hypoglycemic and antihyperglycemic activities in the hyperglycemic experimental models tested

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Author Biography

Roberto Kenji Nakamura Cuman, Farmácia/Análises Clínicas - UEM

Possui graduação em Farmácia pela Universidade Federal do Rio Grande do Sul (1984), mestrado em Farmacologia pela Universidade de São Paulo (1993) e doutorado em Farmacologia pela Universidade de São Paulo (1998). Atualmente é Diretor Presidente da Fundação de Apoio Ao Desenvolvimento Científico da Universidade Estadual de e professor associado da Universidade Estadual de Maringá. Tem experiência na área de Farmacologia, com ênfase em Farmacologia Geral, atuando principalmente nos seguintes temas: diabetes tipo 2, inflamação, diabetes, farmacoepidemiologia e inflamacao. Currículo Lattes

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Published

2008-03-26

How to Cite

Gonçalves, S. T., Baroni, S., Bersani-Amado, F. A., Sartoretto, J. L., Cortez, D. A. G., Fernandes, C. A. M., Bersani-Amado, C. A., & Cuman, R. K. N. (2008). Evaluation of hypoglycemic and antihyperglycemic activities in hydroethanolic extract of <em>Averrhoa carambola</em> L. (Oxalidaceae) in experimental models of hyperglycemia. Acta Scientiarum. Health Sciences, 27(1), 49-55. https://doi.org/10.4025/actascihealthsci.v27i1.1443

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Issue

Vol 27 No 1 (2005)

Section

Pharmacy

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