Atividade farmacológica do extrato hidroetanólico liofilizado de caule de Kielmeyera coriacea em ratos - DOI: 10.4025/actascihealthsci.v26i2.1591

Juliana Vanessa Colombo Martins; Fernanda Jacques Otobone; Vania Ramos Sela; Simoni Obici; Marcos Alberto Trombelli; Diógenes Aparício Garcia Cortez; Elisabeth Aparecida Audi

doi:10.4025/actascihealthsci.v26i2.1591

Activity of hydroethanolic extract from Kielmeyera coriacea stems on central nervous system in rats - DOI: 10.4025/actascihealthsci.v26i2.1591

Juliana Vanessa Colombo Martins UEM
Fernanda Jacques Otobone UEM
Vania Ramos Sela UEM
Simoni Obici UEM
Marcos Alberto Trombelli UEM
Diógenes Aparício Garcia Cortez UEM
Elisabeth Aparecida Audi UEM

DOI: https://doi.org/10.4025/actascihealthsci.v26i2.1591

Abstract

The aim of the present study was to investigate psychotropic properties of the crude lyophilized hydroethanolic extract (HE) from Kielmeyera coriacea stems after acute or chronic administration by oral route (gavage) in rats. Anxiolytic, antidepressive and psychomotor stimulant effects were evaluated using Plus-Maze (PMT), Forced Swimming (FST) and Open Field (OFT) test experimental models, respectively. Evaluation of the extract stems (60.0 mg/kg) revealed decreased immobility time in the forced swimming test (FST), without increasing locomotor activity in OFT, after chronic administration. This effect of the extract was compared with imipramine (20.0 mg/kg). Acute administration of 120.0 mg/kg of extract stems increased the open arm entries percentage in the PMT. According to the results, Kielmeyera coriacea stems extract is effective as anxiolytic as well as an anti-depressive-like drugs.

Downloads

Download data is not yet available.

Author Biography

Elisabeth Aparecida Audi, UEM

Graduada em Ciências Biológicas pela Universidade Estadual de Londrina (1980), com mestrado e doutorado pelo departamento de Farmacologia da Faculdade de Medicina da Universidade de São Paulo (1984/1987). Pós doutorado no Synthelabo-Recherche (1993). Professora associada C da Universidade Estadual de Maringá. Pesquisadora na área de Neuropsicofarmacologia, com ênfase em Substratos Neurais da Ansiedade e Depressão e envolvimento da serotonina no mecanismo de ação de antidepressivos Currículo Lattes

PDF (Português (Brasil))

Published

2008-03-31

How to Cite

Martins, J. V. C., Otobone, F. J., Sela, V. R., Obici, S., Trombelli, M. A., Cortez, D. A. G., & Audi, E. A. (2008). Activity of hydroethanolic extract from Kielmeyera coriacea stems on central nervous system in rats - DOI: 10.4025/actascihealthsci.v26i2.1591. Acta Scientiarum. Health Sciences, 26(2), 365-368. https://doi.org/10.4025/actascihealthsci.v26i2.1591

Download Citation

Issue

Vol 26 No 2 (2004)

Section

Pharmacy

DECLARATION OF ORIGINALITY AND COPYRIGHTS

I Declare that current article is original and has not been submitted for publication, in part or in whole, to any other national or international journal.

The copyrights belong exclusively to the authors. Published content is licensed under Creative Commons Attribution 4.0 (CC BY 4.0) guidelines, which allows sharing (copy and distribution of the material in any medium or format) and adaptation (remix, transform, and build upon the material) for any purpose, even commercially, under the terms of attribution.

Read this link for further information on how to use CC BY 4.0 properly.

<b>Activity of hydroethanolic extract from <em>Kielmeyera coriacea</em> stems on central nervous system in rats</b> - DOI: 10.4025/actascihealthsci.v26i2.1591

Abstract

Downloads

Author Biography