<b><em>in vitro</em> activity of antifungal agents on yeasts isolated from vaginal secretion</b> - DOI: 10.4025/actascihealthsci.v25i1.2298

Abstract

Vulvovaginal candidiasis (VVC) is the second most frequent cause of vaginal infection, having high incidence and recurrence, which requires longer treatments. The genus Candida, specially the species C. albicans, is the most common agent. However, other species, more difficult to eradicate, may also be involved. The aim of this study was to determine the frequency of vaginal colonization by yeasts and to evaluate susceptibility to three drugs, which are indicated for the VVC treatment. Vaginal secretion was collected from four hundred and twelve unselected women. The overall rate of yeast colonization was 20.15%. Candida albicans was the most frequent (84%), followed by C. glabrata (7%), C. tropicalis (4%), Torulopsis sp (2%), C. parapsilosis (2%) and S. cerevisiae (1%). In vitro susceptibility tests revealed that 96,4% of the isolated yeasts were susceptible to fluconazole, 71% to nistatin and 98,8% to amphotericin B.