Os antígenos HLA e a hemoterapia

Elide Aparecida de Oliveira; Ana Maria Sell

doi:10.4025/actascihealthsci.v24i0.2510

HLA antigens and transfusion therapy

Elide Aparecida de Oliveira UEM
Ana Maria Sell UEM

DOI: https://doi.org/10.4025/actascihealthsci.v24i0.2510

Abstract

HLA molecules or antigens are cellular surface glycoproteins that are involved in the regulation of immune reaction. The HLA complex includes the most polymorphic genes in human. As in the last years we observed a large increase in the transfusions therapy, due the use of the chemotherapeutic agents and the safety of the procedure, the alloimunization has been subject of study. The aim of this work was to revise basic aspects of the system HLA and its role in the transfusion therapy. In order to achieve it, immunological factors involved in the alloimunization and the immunomodulation were approached, emphasizing platelet transfusion therapy in refractory patient, the development of the graft-versus- host disease, the influence of the allossensibilization in the transplants and the importance of the allogenic transfusion in the recurrent miscarriage

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Author Biography

Ana Maria Sell, UEM

Possui graduação em Farmácia e Bioquímica pela Universidade Federal de Juiz de Fora (1982) , mestrado em Agroquímica pela Universidade Federal de Viçosa (1988) e doutorado em Biologia Patologia Buco-Dental pela Universidade Estadual de Campinas (1998) . Atualmente é Professor Adjunto da Universidade Estadual de Maringá. Tem experiência na área de Imunologia , com ênfase em Imunogenética. Atuando principalmente nos seguintes temas: lectinas, reparação tecidual, PHA, WGA, artocarpina Currículo Lattes

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Published

2008-04-24

How to Cite

de Oliveira, E. A., & Sell, A. M. (2008). HLA antigens and transfusion therapy. Acta Scientiarum. Health Sciences, 24, 731-736. https://doi.org/10.4025/actascihealthsci.v24i0.2510

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Issue

Vol 24 (2002)

Section

Health Sciences

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