<b>A non-linear mixed-effects model to describe the effect of acarbose intake on postprandial glycaemia in a single rat

Omar Cléo Neves Pereira; Paulo Vitor da Costa Pereira; Mauricio Fumio Sybuia; Emerson Barili; Rosangela Santana; Isolde Previdelli

doi:10.4025/actascihealthsci.v39i1.27431

<b>A non-linear mixed-effects model to describe the effect of acarbose intake on postprandial glycaemia in a single rat

Omar Cléo Neves Pereira Universidade Estadual de Maringá,
Paulo Vitor da Costa Pereira Universidade Estadual de Maringá
Mauricio Fumio Sybuia Universidade Estadual de Maringá
Emerson Barili Universidade Estadual de Maringá
Rosangela Santana Universidade Estadual de Maringá
Isolde Previdelli Universidade Estadual de Maringá

DOI: https://doi.org/10.4025/actascihealthsci.v39i1.27431

Keywords: Diabetes mellitus, glucose, small sample, two-compartment model.

Abstract

A non-linear mixed-effects model is proposed to assess the impact of acarbose over time on postprandial glycaemia in a single rat. The model is based on two compartments, one representing the entry of glucose in the blood and the other its exit. The rat was submitted to two treatments: ingestion of starch and ingestion of starch plus acarbose. The model showed great suitability, with inferences on the behavior of glucose levels in response to treatments and supplying a richer description than just the area under the curve. The marginal curves for the two treatments are similar during the first moments; however, after reaching the peak of glucose concentration, they progressively became separate due to acarbose treatment and reached the initial levels more quickly. The proposed model, albeit with a single sample unit, showed similar results to those with larger samples; in other words, acarbose significantly attenuates glycaemia after ingestion of starch.

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Author Biography

Omar Cléo Neves Pereira, Universidade Estadual de Maringá,

Na Universidade Estadual de Maringá concluiu graduação em Agronomia (1988), bacharelado em Física (2008), mestrado em Agronomia (2001), mestrado em Física (2011) e doutorado em Agronomia (2006). Na Faculdade Integrada da Grande Fortaleza concluiu licenciatura em Física (2013).

Published

2017-05-31

How to Cite

Pereira, O. C. N., Pereira, P. V. da C., Sybuia, M. F., Barili, E., Santana, R., & Previdelli, I. (2017). <b>A non-linear mixed-effects model to describe the effect of acarbose intake on postprandial glycaemia in a single rat. Acta Scientiarum. Health Sciences, 39(1), 1-7. https://doi.org/10.4025/actascihealthsci.v39i1.27431

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Issue

Vol 39 No 1 (2017)

Section

Health Sciences

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