Estudo da degradação do fármaco Nabumetona por fotólise direta

Cristiane Moriwaki; Edeilza Gomes Brescansin; Noboru Hioka; Florangela Maionchi; Graciette Matioli

doi:10.4025/actascihealthsci.v23i0.2897

Study of Nabumetone degradation through direct photolysis

Cristiane Moriwaki UEM
Edeilza Gomes Brescansin UEM
Noboru Hioka UEM
Florangela Maionchi UEM
Graciette Matioli UEM

DOI: https://doi.org/10.4025/actascihealthsci.v23i0.2897

Abstract

The present work aims to study the degradation of Nabumetone through direct photolysis. Solutions of Nabumetone in ethanol (20 mg/mL) were prepared and divided in quartz cuvettes with teflon lids. These were placed in the photolysis cabinet at 35ºC. The photodegradation quantifications were analyzed in High Performance Liquid Cromatography (HPLC); after 47 days of photolysis the sample degradation was 67%, after 73 days 88.5% and after 111 days 89.5%. Spectrophotometers determinations (240 to 360 nm) were accomplished after 28, 47 and 73 days of photolysis. The photoproducts were separate for HPLC and analyzed by Gas Cromatograph coupled to Mass Spectrometer (GC-MS). The analysis in GC-MS of the Nabumetona photolyseded for 111 days allowed the suggestion of two substances.

Downloads

Download data is not yet available.

Author Biography

Graciette Matioli, UEM

Possui graduação em Farmácia Bioquímica pela Universidade Estadual de Maringá (1985), mestrado em Ciências de Alimentos pela Universidade Estadual de Londrina (1991), doutorado em Ciências (Bioquímica) pela Universidade Federal do Paraná (1997) e pós-doutorado em Ciências de Alimentos pela Universidade Estadual de Campinas (2001). Atualmente é Professora Associada nível A - TIDE da Universidade Estadual de Maringá. Tem experiência na área de Farmácia Industrial, com ênfase em Biotecnologia e Ciências de Alimentos, atuando principalmente nos seguintes temas: ciclodextrina, ciclodextrina glicosiltransferase, enzimas, ciëncias de alimentos, complexos de inclusao, alimentos funcionais Currículo Lattes

PDF (Português (Brasil))

Published

2008-05-06

How to Cite

Moriwaki, C., Brescansin, E. G., Hioka, N., Maionchi, F., & Matioli, G. (2008). Study of Nabumetone degradation through direct photolysis. Acta Scientiarum. Health Sciences, 23, 651-654. https://doi.org/10.4025/actascihealthsci.v23i0.2897

Download Citation

Issue

Vol 23 (2001)

Section

Health Sciences

DECLARATION OF ORIGINALITY AND COPYRIGHTS

I Declare that current article is original and has not been submitted for publication, in part or in whole, to any other national or international journal.

The copyrights belong exclusively to the authors. Published content is licensed under Creative Commons Attribution 4.0 (CC BY 4.0) guidelines, which allows sharing (copy and distribution of the material in any medium or format) and adaptation (remix, transform, and build upon the material) for any purpose, even commercially, under the terms of attribution.

Read this link for further information on how to use CC BY 4.0 properly.