<b>Expression of genes related to the adrenocortical function in the neoplastic cachexia process</b>- DOI: 10.4025/actascihealthsci.v31i2.6759
Keywords:
adrenal glands, cachexia, corticotropin receptors, 3-hydroxysteroid dehydrogenases, translocator protein, steroidogenic acute regulatory protein
Abstract
The adrenal gland plays a crucial role in the neuroendocrine response, especially in situations where homeostasis is disturbed. In the neoplastic cachexia process, there is homeostasis impairment by nutritional and metabolic alterations of advanced-stage cancer, involving hypothalamus-pituitary-adrenal axis response. In this assignment, an experimental model of cachexia induced by Walker-256 tumor was performed in Wistar rats. Animals (n=4) were sacrificed 10 days after inoculation of tumor cells, and the adrenal glands were excised. The RNA was isolated for the study of gene expression related to the steroidogenesis control by semi-quantitative RT-PCR. Data analysis showed a significant reduced expression of MC2R (melancortin type 2 receptor), 3ßHSD I (3-beta-hydroxysteroid dehydrogenase type I) and TSPO (translocator protein) genes in animals with neoplastic cachexia (P=0.037, 0.0097 and 0.052, respectively), revealing adrenal cortex failure.Downloads
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Published
2009-09-17
How to Cite
Scripes, N. de A., Macioszek, M. A., Bahls, L. D., Aoki, M. N., Watanabe, M. A. E., & Mazzuco, T. L. (2009). <b>Expression of genes related to the adrenocortical function in the neoplastic cachexia process</b>- DOI: 10.4025/actascihealthsci.v31i2.6759. Acta Scientiarum. Health Sciences, 31(2), 133-141. https://doi.org/10.4025/actascihealthsci.v31i2.6759
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Section
Medicine
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