Development and validation of the analytical method by high performance liquid chromatography (HPLC) for Lamotrigine raw material

Guilherme Nobre Lima do Nascimento; Keyla Carla de Freitas Pereira; Hisao Nishijo; Tales Alexandre Aversi-Ferreira

doi:10.4025/actascihealthsci.v33i2.8244

Development and validation of the analytical method by high performance liquid chromatography (HPLC) for Lamotrigine raw material

Guilherme Nobre Lima do Nascimento Universidade Federal de Goiás
Keyla Carla de Freitas Pereira Universidade Federal de Goiás
Hisao Nishijo University of Toyama
Tales Alexandre Aversi-Ferreira University of Toyama

DOI: https://doi.org/10.4025/actascihealthsci.v33i2.8244

Keywords: Validation, Lamotrigine, HPLC, phenylthiazinic

Abstract

Currently when all roads lead to the pursuit of total quality in production of drugs, it is essential to fully understand each phase of a production process. In this case, validation is the appropriate tool to ensure reliability of a production process involving new equipment and the analytical methodology, either in the pharmaceutical, food, computer, microelectronics area or any other area where the quality of the manufactured product is one of the main reasons for the existence of a given company. This study aimed to analyze the main aspects of the validation of analytical methods for Lamotrigine, new drug for bipolar disorder with wide use today. In conclusion, the proposed analytical method for determination of the lamotrigine content in raw materials is adequate, effective and capable of reproducing reliable results during analysis. This method is fast (running time of 10 minutes), selective, accurate, precise and robust for the determination of the drug, with no observed interfering substances in the optimum wavelength. It could be concluded that this may be a routine method for quality control laboratories to certify the quality of Lamotrigine.

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Author Biography

Guilherme Nobre Lima do Nascimento, Universidade Federal de Goiás

Possui graduação em Ciências Biológicas pela Universidade Federal de Uberlândia (1994), mestrado em Biologia pela Universidade Federal de Goiás (2001) e doutorado em Genética e Bioquímica pela Universidade Federal de Uberlândia (2004). Cursando doutorado em Química Quântica na Universidade Federal de Goiás. Atualmente é revisor da revista Bioscience Journal (UFU) (1516-3725) e Revista Eletrônica de Farmácia da UFG, editor da revista Neurociências de Goiânia; professor adjunto da Universidade Federal de Goiás. Tem experiência na área de Neurofarmacologia, Morfologia e Bioquímica, com ênfase em Neurofisiologia, Neuroanatomia, Neuroquímica e Neurotoxicologia, atuando principalmente nos seguintes temas: Cebus, anatomia, sistema neural, etanol, toxicologia, termodinâmica e química teórica Currículo Lattes

Published

2011-03-29

How to Cite

Nascimento, G. N. L. do, Pereira, K. C. de F., Nishijo, H., & Aversi-Ferreira, T. A. (2011). Development and validation of the analytical method by high performance liquid chromatography (HPLC) for Lamotrigine raw material. Acta Scientiarum. Health Sciences, 33(2), 153-157. https://doi.org/10.4025/actascihealthsci.v33i2.8244

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Issue

Vol 33 No 2 (2011)

Section

Pharmacy

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