PHYSIOPATOLOGICAL ASPECTS OF COVID-19 IN HUMANS
Keywords:
coronavirus, pneumonia, viremia, inflammation, one health
Abstract
In December 2019, the largest epidemic associated with a Coronavirus began, SARS-CoV-2 (better known as COVID-19, or Coronavirus Disease / 2019). The first focus was in Hubei province, China, and since then it has spread throughout the world, reaching, until April 2020, almost 2.8 million people and approximately 193 thousand deaths worldwide. The agent causes respiratory, hemodynamic, digestive and inflammatory disorders, which can lead to death in any individual, although the lethality rate is higher in individuals over 60 years and with some comorbidity, such as diabetes or previous cardiac problems. The present study describes the pathogenesis of the agent and the anatomopathological lesions induced by COVID-19 in humans.
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References
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JANKA, G. E. e LEHMBERG,K. Hemophagocytic syndromes – An update. Blood Reviews, v. 28, n.4, p135-142, 2014.
LIN L.; LU L.; CAO W.; LI T. Hypothesis for potential pathogenesis of SARS-CoV-2 infection--a review of immune changes in patients with viral pneumonia. Emerging Microbes & Infections. 2020:1-14
LUAN,J.; LU, Y.; JIN, X.; ZHANG, L. Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection Biochemical and Biophysical Research Communications 526 (2020) 165e1699
MEHTA P.; MCAULEY D.F.; BROWN M.; SANCHEZ E.; TATTERSALL R.S.; MANSON J.J. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. March, 13, 2020. https://doi.org/10.1016/S0140-6736(20)30628-0
OMS Organização Mundial de Saúde https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200426-sitrep-97-covid-19.pdf?sfvrsn=d1c3e800_6 , acesso em 26 de abril de 2020.
PINTO, B. G. G.; OLIVEIRA, A. E. R.; SINGH, Y.; JIMENEZ, L.; GONCALVES, A. N. A.; OGAVA, R. L.T.; CREIGHTON, R.; PERON, J. P. S.; NAKAYA, H. I. ACE2 Expression is Increased in the Lungs of Patients with Comorbidities Associated with Severe COVID-19 doi: https://doi.org/10.1101/2020.03.21.20040261 acesso em 16/04/2020
SIDDIQI, H. K. E MEHRA, M. R. COVID-19 Illness in Native and Immunosuppressed States: A Clinical-Therapeutic Staging Proposal, Journal of Heart and Lung Transplantation (2020), doi: https://doi.org/10.1016/j.healun.2020.03.012
TIAN S.; HU W.; NIU L.; LIU H.,; XU H.; XIAO S.Y. Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer. J Thorac Oncol 2020; published online Feb 28. DOI:10.1016/j.jtho.2020.02.010.
ZHENG, J. SARS-CoV-2: an Emerging Coronavirus That Causes a Global Threat. International Journal of Biological Sciences. 2020; 16(10):1678-1685 Published online 2020 Mar 15. doi: 10.7150/ijbs.45053 Acesso em 16 de abril de 2020.
ZHOU, G.; CHEN, S.; CHEN, Z. Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies. Front. Med. https://doi.org/10.1007/s11684-020-0773-x 2020
ZORZETTO, R. Os danos do coronavirus https://revistapesquisa.fapesp.br/2020/04/01/os-danos-do-coronavirus/, acesso em 16/04/2020
Published
2020-08-28
How to Cite
de Oliveira Torres Carrasco, A., Christina Seki, M., Mitalli Tomacheuski, R., & Cristina Mazzucatto, B. (2020). PHYSIOPATOLOGICAL ASPECTS OF COVID-19 IN HUMANS. Revista De Ciência Veterinária E Saúde Pública, 7(1), 049-053. https://doi.org/10.4025/revcivet.v7i1.55498
Section
Artigos Originais
Declaro que o presente artigo é original, não tendo sido submetido à publicação em qualquer outro periódico nacional ou internacional, quer seja em parte ou em sua totalidade. Declaro, ainda, que uma vez publicado na revista Arquivo de Medicina veterinária e Saúde Pública da UEM, editada pela Universidade Estadual de Maringá, o mesmo jamais será submetido por mim ou por qualquer um dos demais co-autores a qualquer outro periódico. Através deste instrumento, em meu nome e em nome dos demais co-autores, porventura existentes, cedo os direitos autorais do referido artigo à Universidade Estadual de Maringá e declaro estar ciente de que a não observância deste compromisso submeterá o infrator a sanções e penas previstas na Lei de Proteção de Direitos Autorias (Nº9609, de 19/02/98).
