The Antifungal profiling of Brazilian essential oils: Chemotype classification and correlation with bioactivity

Authors

  • Matteo Henrique Sartore Universidade de São Paulo
  • Leticia Rodrigues Barrozo Lopes Universidade de São Paulo
  • Marcelo José Pena Ferreira Universidade de São Paulo
  • Cristina de Castro Spadari Universidade de São Paulo
  • Kelly Ishida Universidade de São Paulo
  • Marcelo Marucci Pereira Tangerina Universidade de São Paulo
  • Eutimio Gustavo Fernández Núñez Universidade de São Paulo
  • Miriam Sannomiya Universidade de São Paulo

Keywords:

CG-MS, chemotypes, essential oil, Melaleuca alternifolia, multivariate data analysis, antifungal activity

Abstract

Seven Brazilian commercial samples of tea tree oil (TTO) from Melaleuca alternifolia were analyzed from the chemical perspective to identify their chemotypes, and their efficacy against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus by the broth microdilution method was also explored. Principal component analysis (PCA), hierarchical cluster analysis (HCA), and partial least squares (PLS) were performed to identify similarities and differences among the samples and their correlation with the antifungal activity. According to the chemical composition, 86 % of the samples analyzed are classified as chemotype I, and one of them can suggest an essential oil adulterated with Eucalyptus species. PCA and HCA demonstrated that the TTO samples should be divided into three groups and the major compounds in each group were identified. According to PLS analysis, two samples showed the most antifungal activities against C. albicans and C. neoformans most likely related to the content of 1,8-cineole and p-cymene as an enhancer and an inhibitor, respectively.

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Published

2025-06-17

How to Cite

Sartore, M. H. ., Lopes, L. R. B. ., Ferreira, M. J. P. ., Spadari, C. de C. ., Ishida, K. ., Tangerina, M. M. P. ., Fernández Núñez, E. G. ., & Sannomiya, M. . (2025). The Antifungal profiling of Brazilian essential oils: Chemotype classification and correlation with bioactivity. Acta Scientiarum. Technology, 47(1), e71290. Retrieved from https://periodicos.uem.br/actascitechnol/index.php/ActaSciTechnol/article/view/71290

Issue

Vol. 47 No. 1 (2025): Publicação contí­nua

Section

Chemistry

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Copyright (c) 2024 Matteo Henrique Sartore, Leticia Rodrigues Barrozo Lopes, Marcelo José Pena Ferreira, Cristina de Castro Spadari, Kelly Ishida, Marcelo Marucci Pereira Tangerina, Eutimio Gustavo Fernández Núñez, Miriam Sannomiya (Autor)

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