<b>Estimation of partition, free and specific diffusion coefficients of paclitaxel and taxanes in a fixed bed by moment analysis: experimental, modeling and simulation studies</b> - doi: 10.4025/actascitechnol.v34i1.8060

Authors

  • Marco Aurélio Cremasco Universidade Estadual de Campinas
  • Linda Nien-Hwa Wang Universidade Estadual de Campinas

DOI:

https://doi.org/10.4025/actascitechnol.v34i1.8060

Keywords:

Cancer, taxol, mass transfe

Abstract

Paclitaxel, as known Taxol®, is an important agent in cancer treatment, founded in mixture with many structural analogs, or taxanes, present in natural source or plant tissue culture broth. The adsorption techniques are used in the purification of placlitaxel from that complex mixture, but despite of the strategy it is important to know the basic parameters associated with any process, such as isotherms and mass transfer parameters. In this paper is presented a simple model to estimate these parameters by moment analysis. After to consider linear isotherm for adsorption, the partition coefficient, free and effective diffusion coefficients of paclitaxel and four major components, in a plant tissue culture broth, were estimated from the first and second moments of peaks in pulse-elution chromatograms. The experimental chromatograms at two flow rates are compared with those ones from model, also proposed in this work. The experimental results of free diffusion coefficient are compared with that ones from the Literature.

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Author Biography

Marco Aurélio Cremasco, Universidade Estadual de Campinas

Possui graduação em Engenharia Quimica pela Universidade Estadual de Maringá (1984), mestrado em Engenharia Quí­mica pela Universidade Federal do Rio de Janeiro (1986), doutorado em Engenharia Mecânica pela Universidade Estadual de Campinas (1994), pós-doutorado em Engenharia Quí­mica (Purdue University-EUA). Livre-docente, é professor associado da Faculdade de Engenharia Quí­mica, Universidade Estadual de Campinas. Possui os livros "Fundamentos de transferência de massa" (Editora da Unicamp),"Vale a pena estudar engenharia quí­mica" (Editora Edgard Blí¼cher), bem como cerca de cem artigos completos publicados e cinco solicitações de patentes. Tem experiência em campos de Engenharia Quí­mica, com ênfase em Transferencia de Massa e Sistemas Particulados. Atua nas seguintes áreas: ensino; adsorção; secagem; tratamento de efluentes por ozonização; leitos fixo, de jorro, fluidizado, circulante; fluidodinâmica em riser e downer para aplicações em processos catalí­ticos.

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Published

2011-07-14

How to Cite

Cremasco, M. A., & Wang, L. N.-H. (2011). <b>Estimation of partition, free and specific diffusion coefficients of paclitaxel and taxanes in a fixed bed by moment analysis: experimental, modeling and simulation studies</b> - doi: 10.4025/actascitechnol.v34i1.8060. Acta Scientiarum. Technology, 34(1), 33–40. https://doi.org/10.4025/actascitechnol.v34i1.8060

Issue

Vol. 34 No. 1 (2012)

Section

Chemical Engineering

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