Avaliação da toxicidade subcrônica do extrato bruto seco de Anacardium occidentale Linn em cães - DOI: 10.4025/actascihealthsci.v28i1.1112

Arquimedes Fernandes Monteiro de Melo; Miracy Muniz Albuquerque; Maria Almerice Lopes da Silva; Gracielle Carvalho Gomes; Isabely de Souza Vera Cruz; Vanessa Ribeiro Leite; Jane Sheila Higino

doi:10.4025/actascihealthsci.v28i1.1112

**Evaluation of the subchronic toxicity of the crude dry extract of Anacardium occidentale Linn in dogs** - DOI: 10.4025/actascihealthsci.v28i1.1112

Authors

Arquimedes Fernandes Monteiro de Melo UFPE Author
Miracy Muniz Albuquerque UFPE Author
Maria Almerice Lopes da Silva UFPE Author
Gracielle Carvalho Gomes UFPE Author
Isabely de Souza Vera Cruz UFPE Author
Vanessa Ribeiro Leite UFPE Author
Jane Sheila Higino UFPE Author

DOI:

https://doi.org/10.4025/actascihealthsci.v28i1.1112

Keywords:

Anacardium occidentale Linn, cajueiro, toxicidade, subcrônica, produtos naturais, atividade biológica

Abstract

Research on new medicaments has led to the development of efficient and non-toxic drugs. In Brazil, the Agência Nacional de Vigilância Sanitária (National Department of Sanitary Supervision – ANVISA) regularizes and standardizes the procedure. Anacardium occidentale is amongst the most researched plants, due to the antibiotics and antinflammatory properties of its secondary metabolites, mainly tannins and flavonoids. Furthermore, it prevents the dental plaque formation. On account of these actions, finished pharmaceutical forms (creams and gels) were developed from the crude dry extract (CDE) of A. occidentale Linn stem rinds, in order to register a new form. However, pre-clinical and clinical assays can be made in accordance with the effective law. The present work evaluated the subchronic toxicity of the CDE in dogs of indefinite pedigree. Data showed an increase of alanine transaminase (ALT) and aspartate transaminase (AST) levels, which may indicate transitory hepatotoxicity

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Author Biography

Arquimedes Fernandes Monteiro de Melo, UFPE

possui graduação em Farmácia pela Universidade Federal de Pernambuco (1994), mestrado em Ciências Farmacêuticas pela Universidade Federal de Pernambuco (2002) e doutorado em Produtos Naturais e Sintéticos Bioativos pela Universidade Federal da Paraíba (2005). Atualmente é professor adjunto da Universidade de Pernambuco, e da Associação Caruaruense de Ensino Superior. Tem experiência na área de Farmácia, com ênfase em Farmacologia e Toxicologia de Plantas Medicinais e Ambiental, atuando principalmente nos seguintes temas: toxicidade de medicamentos, de plantas medicinais e fitoterápicos Currículo Lattes

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Published

2008-03-13

Issue

Vol. 28 No. 1 (2006)

Section

Pharmacy

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How to Cite

Fernandes Monteiro de Melo, A., Muniz Albuquerque, M., Lopes da Silva, M. A., Carvalho Gomes, G., de Souza Vera Cruz, I., Ribeiro Leite, V., & Higino, J. S. (2008). Evaluation of the subchronic toxicity of the crude dry extract of Anacardium occidentale Linn in dogs - DOI: 10.4025/actascihealthsci.v28i1.1112. Acta Scientiarum. Health Sciences, 28(1), 37-41. https://doi.org/10.4025/actascihealthsci.v28i1.1112