Estudo da degradação do fármaco Nabumetona por fotólise direta

Cristiane Moriwaki; Edeilza Gomes Brescansin; Noboru Hioka; Florangela Maionchi; Graciette Matioli

doi:10.4025/actascihealthsci.v23i0.2897

Study of Nabumetone degradation through direct photolysis

Authors

Cristiane Moriwaki UEM Author
Edeilza Gomes Brescansin UEM Author
Noboru Hioka UEM Author
Florangela Maionchi UEM Author
Graciette Matioli UEM Author

DOI:

https://doi.org/10.4025/actascihealthsci.v23i0.2897

Keywords:

estabilidade de medicamentos, fotólise, fotoprodutos, nabumetona

Abstract

The present work aims to study the degradation of Nabumetone through direct photolysis. Solutions of Nabumetone in ethanol (20 mg/mL) were prepared and divided in quartz cuvettes with teflon lids. These were placed in the photolysis cabinet at 35ºC. The photodegradation quantifications were analyzed in High Performance Liquid Cromatography (HPLC); after 47 days of photolysis the sample degradation was 67%, after 73 days 88.5% and after 111 days 89.5%. Spectrophotometers determinations (240 to 360 nm) were accomplished after 28, 47 and 73 days of photolysis. The photoproducts were separate for HPLC and analyzed by Gas Cromatograph coupled to Mass Spectrometer (GC-MS). The analysis in GC-MS of the Nabumetona photolyseded for 111 days allowed the suggestion of two substances.

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Author Biography

Graciette Matioli, UEM

Possui graduação em Farmácia Bioquímica pela Universidade Estadual de Maringá (1985), mestrado em Ciências de Alimentos pela Universidade Estadual de Londrina (1991), doutorado em Ciências (Bioquímica) pela Universidade Federal do Paraná (1997) e pós-doutorado em Ciências de Alimentos pela Universidade Estadual de Campinas (2001). Atualmente é Professora Associada nível A - TIDE da Universidade Estadual de Maringá. Tem experiência na área de Farmácia Industrial, com ênfase em Biotecnologia e Ciências de Alimentos, atuando principalmente nos seguintes temas: ciclodextrina, ciclodextrina glicosiltransferase, enzimas, ciÃ«ncias de alimentos, complexos de inclusao, alimentos funcionais Currículo Lattes

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PDF (Portuguese)

Published

2008-05-06

Issue

Vol. 23 (2001)

Section

Health Sciences

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How to Cite

Study of Nabumetone degradation through direct photolysis. (2008). Acta Scientiarum. Health Sciences, 23, 651-654. https://doi.org/10.4025/actascihealthsci.v23i0.2897