Pequeno comprometimento do encéfalo em ratos Holtzman imunossuprimidos e infectados por Trypanosoma cruzi - DOI: 10.4025/actascihealthsci.v31i1.831

João Roberto da Mata; Fabiana Ribeiro da Mata; Guilherme Nobre Lima do Nascimento; Tales Alexandre Aversi-Ferreira

doi:10.4025/actascihealthsci.v31i1.831

Encephalic damage in Holtzman rats submitted to immunosuppression and infected by Trypanosoma cruzi - DOI: 10.4025/actascihealthsci.v31i1.831

Authors

João Roberto da Mata UFG Author
Fabiana Ribeiro da Mata UFG Author
Guilherme Nobre Lima do Nascimento pós-graduação em Ciências Farmacêuticas Author
Tales Alexandre Aversi-Ferreira UFG Author

DOI:

https://doi.org/10.4025/actascihealthsci.v31i1.831

Keywords:

immunosuppression, T. cruzi, encephalon, Holtzman rats

Abstract

American trypanosomiasis is still a public health problem in Brazil and Latin America. The infection depends on the characteristics of each isolate of Trypanosoma cruzi and its host. The hypothesis of central nervous system (CNS) tropism has been proposed for certain strains. This work tested the infection rate of the encephalon of immunosuppressed Holtzman rats. The Y and PNM strains were used as well as the CL-Brener clone, inoculated in Holtzman rats irradiated (700 rad gamma) at 29 days of age and inoculated at 30 days of age. Immunosuppression increased the parasitemia by T. cruzi on SNC for all analyzed strains in comparison to the control animals. Neurotropism not was verified of T. cruzi under these conditions as in the literature. The parasitemia detected in the SNC was small compared to literature data, perhaps due to the short time of parasite exposure.

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Author Biography

João Roberto da Mata, UFG

Tem experiência na área de Morfologia, com ênfase em Anatomia Humana, atuando principalmente nos seguintes temas: Doença de Chagas Experimental, Sistema Neural, Neuroanatomia, Neurocomportamento do Macaco cebus. Currículo Lattes

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Published

2009-05-07

Issue

Vol. 31 No. 1 (2009)

Section

Pharmacy

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How to Cite

Mata, J. R. da, Mata, F. R. da, Nascimento, G. N. L. do, & Aversi-Ferreira, T. A. (2009). Encephalic damage in Holtzman rats submitted to immunosuppression and infected by Trypanosoma cruzi - DOI: 10.4025/actascihealthsci.v31i1.831. Acta Scientiarum. Health Sciences, 31(1), 45-50. https://doi.org/10.4025/actascihealthsci.v31i1.831