<b>Encephalic damage in Holtzman rats submitted to immunosuppression and infected by <em>Trypanosoma cruzi</em></b> - DOI: 10.4025/actascihealthsci.v31i1.831
Keywords:
immunosuppression, T. cruzi, encephalon, Holtzman rats
Abstract
American trypanosomiasis is still a public health problem in Brazil and Latin America. The infection depends on the characteristics of each isolate of Trypanosoma cruzi and its host. The hypothesis of central nervous system (CNS) tropism has been proposed for certain strains. This work tested the infection rate of the encephalon of immunosuppressed Holtzman rats. The Y and PNM strains were used as well as the CL-Brener clone, inoculated in Holtzman rats irradiated (700 rad gamma) at 29 days of age and inoculated at 30 days of age. Immunosuppression increased the parasitemia by T. cruzi on SNC for all analyzed strains in comparison to the control animals. Neurotropism not was verified of T. cruzi under these conditions as in the literature. The parasitemia detected in the SNC was small compared to literature data, perhaps due to the short time of parasite exposure.Downloads
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Published
2009-05-07
How to Cite
Mata, J. R. da, Mata, F. R. da, Nascimento, G. N. L. do, & Aversi-Ferreira, T. A. (2009). <b>Encephalic damage in Holtzman rats submitted to immunosuppression and infected by <em>Trypanosoma cruzi</em></b> - DOI: 10.4025/actascihealthsci.v31i1.831. Acta Scientiarum. Health Sciences, 31(1), 45-50. https://doi.org/10.4025/actascihealthsci.v31i1.831
Issue
Section
Pharmacy
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