EXPOSURE OF YOUNG ANIMALS TO NUTRITIVE AND NON- NUTRITIVE SWEETENERS AND THEIR METABOLIC EFFECTS IN ADULTHOOD

  • Luana Constantinov Jamarino
  • Letícia Ferreira Barbosa
  • Carolina Santos Campos de Oliveira
  • Eduardo de Oliveira Santos
  • Cecília Edna Mareze-Costa

Resumo

Sucralose (SCL) is one of the most widely used edulcorants in the world, including by
children and adolescents, but its effects on metabolic programming are not sufficient and
conclusive. In this study we evaluated whether ingestion of SCL or sucrose (SUC) by young
rats interferes with metabolic parameters in the adult rat. We used 21-day-old male wistar
rats, which received pure water (control) or water added SUC or SCL, until 60 days of age.
When they reached 90 days of age, half of the animals were fed a high fat diet (HFD). The
animals were euthanized at 120 days of age. When fed only the standard diet, SUC intake in
the young phase caused significant (p<0,05; ANOVA) increase in body weight (11%),
adiposity (48%), insulinemia (53%) and insulin resistance (56%) and reduced lipolytic
response to adrenergic stimulation (53%) in the adult animal. When fed the HFD diet, both
sweeteners causing significant (p<0,05; ANOVA) increases in adiposity (SUC=32%;
SCL=36%) and liver fat (SUC=34%; SCL=41%), with increased insulinemia (75%) only in
the SLC group. We conclude that adding SUC and SCL to the diet during youth may increase
the risks of obesity, insulin resistance and hepatic steatosis in adulthood and accentuate the
metabolic disturbances caused by HFD diets.

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Referências

1st International Symposium of DOHaD & Pandemic: Lessons from COVID-19
Publicado
2023-05-10
Como Citar
1.
Constantinov Jamarino L, Ferreira Barbosa L, Santos Campos de Oliveira C, de Oliveira Santos E, Edna Mareze-Costa C. EXPOSURE OF YOUNG ANIMALS TO NUTRITIVE AND NON- NUTRITIVE SWEETENERS AND THEIR METABOLIC EFFECTS IN ADULTHOOD. arqmudi [Internet]. 10º de maio de 2023 [citado 6º de setembro de 2025];27(ESPECIAL1). Disponível em: https://periodicos.uem.br/ojs/index.php/ArqMudi/article/view/68198
Seção
3. Environmental and dietary influences on the onset of noncommunicable diseases