GHSR MODULATION BY LEAP2 IN PERINATAL PHASES IMPACTS GLUCOSE OVERLOAD RESPONSIVENESS IN YOUNG RATS

  • Marcos Divino Ferreira-Junior
  • Keilah Valéria Naves Cavalcante
  • Ariel Penha Carvalho da Mota
  • Maria Eduarda Ribeiro da Silva
  • Isadora Silva Rosa
  • Jose Antonio Barbosa Lima Sobrinho
  • Carlos Henrique Xavier
  • Paulo Matafome
  • Rodrigo Mello Gomes

Resumo

GHSr signaling is involved in the regulation of energy homeostasis. LEAP2, a recently
discovered peptide hormone, counteracts the effects of ghrelin. This study sought to evaluate
the effects of perinatal LEAP2 exposure in young rat offspring. For this, two protocols were
designed to assess the roles of GHSr antagonism during the pregnancy and during the
lactation. Sex-specific impacts on AUC and peak-responses of glucose tolerance tests were
presented. However, no differences were detected in the blood glucose of mixed meal fed
animals. In conclusion, perinatal LEAP2 exposure could impact the glucose-stimulated
insulin secretion in young rats.

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Referências

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Publicado
2023-05-11
Como Citar
1.
Divino Ferreira-Junior M, Valéria Naves Cavalcante K, Penha Carvalho da Mota A, Eduarda Ribeiro da Silva M, Silva Rosa I, Antonio Barbosa Lima Sobrinho J, Henrique Xavier C, Matafome P, Mello Gomes R. GHSR MODULATION BY LEAP2 IN PERINATAL PHASES IMPACTS GLUCOSE OVERLOAD RESPONSIVENESS IN YOUNG RATS. arqmudi [Internet]. 11º de maio de 2023 [citado 6º de setembro de 2025];27(ESPECIAL1). Disponível em: https://periodicos.uem.br/ojs/index.php/ArqMudi/article/view/68227
Seção
4. Pharmacological and non-pharmacological interventions during critical phases