GHSR MODULATION BY LEAP2 IN PERINATAL PHASES IMPACTS GLUCOSE OVERLOAD RESPONSIVENESS IN YOUNG RATS
Resumo
GHSr signaling is involved in the regulation of energy homeostasis. LEAP2, a recently
discovered peptide hormone, counteracts the effects of ghrelin. This study sought to evaluate
the effects of perinatal LEAP2 exposure in young rat offspring. For this, two protocols were
designed to assess the roles of GHSr antagonism during the pregnancy and during the
lactation. Sex-specific impacts on AUC and peak-responses of glucose tolerance tests were
presented. However, no differences were detected in the blood glucose of mixed meal fed
animals. In conclusion, perinatal LEAP2 exposure could impact the glucose-stimulated
insulin secretion in young rats.
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Referências
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