Deficiência de vitamina D e mortalidade cardiovascular na doença renal crônica: revisão integrativa
DOI:
https://doi.org/10.4025/ciencuidsaude.v20i0.50127Palavras-chave:
Deficiência de vitamina D, Mortalidade, Insuficiência Renal CrônicaResumo
Objetivo: analisar os estudos científicos desenvolvidos sobre a deficiência de vitamina D e a mortalidade por causa cardiovascular nas pessoas com doença renal crônica. Método: Trata-se de uma revisão integrativa da literatura a partir das bases de dados LILACS, PubMed, Medline e na biblioteca eletrônica SciELO, utilizando os descritores deficiência de vitamina D, mortalidade cardiovascular e doença renal crônica, sendo selecionados 14 artigos para análise. Resultados: A partir da análise dos artigos selecionados, foi possível identificar que a deficiência de vitamina D e a mortalidade cardiovascular são condições muito frequentes em renais crônicos e, por isso, discutem-se hipóteses de que a correção desta deficiência pode exercer efeitos benéficos sobre a doença e mortalidade cardiovascular nessa população. Conclusão: Há uma intrínseca relação entre a carência de vitamina D e a mortalidade cardiovascular. Entretanto, ainda é discutível se a suplementação de vitamina D reduz a mortalidade cardiovascular nos doentes renais crônicos. Tal hipótese precisa ser testada em ensaios clínicos, ensejando a necessidade de se desenvolver mais pesquisas sobre o tema.
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Referências
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7. Cozzolino M, Covic A, Placencia BM, Konstantinos X. Treatment failure of active vitamin D therapy in chronic kidney disease: Predictive factors. Am J Nephrol. 2015; 42(3):228–236. Doi:https://doi.org/10.1159/000441095
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12. Filho AJI, Melamed ML. Vitamin D andKidneyDisease. Whatweknowandwhatwe do notknowJ BrasNefrol. 2013;323-331. Doi: http://dx.doi.org/10.5935/0101-2800.20130051
13. Mann MC, Hoobs AJ, Hemmelgarn BR, Roberts DJ, Ahmed SB, Rabi DM. Effect of oral vitamin D analogs on mortality and cardiovascular outcomes among adults with chronic kidney disease: a meta-analysis. ClinKidney J. 2014;41–48. Doi: http://dx.doi.org/10.1093/ckj/sfu122
14. Parikh C, Gutgarts V, Eisenberg E, Melamed ML. Vitamin D and Clinical Outcomes in Dialysis. Semin Dial. 2014; 28(6):604–609. Doi:http://dx.doi.org/10.1111/sdi.12446
15. Ferreira A, Aires I, Nolasco F, Machado D, Macário F, Neves PL, et al. Benefits of selective vitamin D receptor activators in kidney transplanted patients. Port J NephrolHypert. 2015; 29(3):194-206. Disponível em: http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S087201692015000300003&lng=en.
16. Sekercioglu N, Busse JW, Sekercioglu MF, Agarwal A, Shaikh S, Lopes LC, et al. Cinacalcet versus standard treatment for chronic kidney disease: a systematic review and metaanalysis. RenFail. 2016; 38(6):857–874. Doi: http://dx.doi.org/10.3109/ 0886022X.2016.1172468
17. Magalhães LP, Reis LMD, Graciolli FG, Pereira BJ, Oliveira RBD, Souza AALD, et al. Predictive Factors of One-Year Mortality in a Cohort of Patients Undergoing Urgent-Start Hemodialysis. PloSOne. 2017; 1(3):1-8. Disponível em: https://observatorio.fm.usp.br/handle/OPI/18996
18. Hou YC, Liu WC, Zheng CM, Yen TH, Lu KC. Role of Vitamin D in Uremic Vascular Calcification. BioMedRes.Int. 2017; 1-11. DOI: https://doi.org/10.1155/2017/2803579
19. Shardlow A, Mclntyre NJ, Fluck RJ, Mclntyre CW, Taal MW. Associations of fibroblast growth factor 23, vitamin D and parathyroid hormone with 5 year outcomes in a prospective primary care cohort of people with chronic kidney disease stage 3. BMJ Open. 2017; 28(4): 83-92. Doi: http://dx.doi.org/10.1136/bmjopen-2017-016528
20. Hamano T. Vitamin D and renal outcome: the fourth outcome of CKD-MBD? Oshima AwardAddress 2015. J ClinExpNephrol .2018; 22(3): 249-256. Doi: http://dx.doi.org/10.1007/s10157-017-1517-3
21. Brzozka AG, Franzyck B, Ryzs AC, Olszewski R, Ryzs J. Impact of Vitamin D on the Cardiovascular System in Advanced Chronic Kidney Disease (CKD) and Dialysis Patients. Nutrients. 2018;10(4):709-718. Doi:http://dx.doi.org/10.3390/nu10060709
22. Chen X, Lu YP, Luo T, Wu HW, Cai SF, Tian M, et al. Free 25-Vitamin D Is Correlated with Cardiovascular Events in Prevalent Hemodialysis Patients but Not with Markers of Renal Mineral Bone Disease. KidneyBlood Press Res. 2019;44(2):344-353.Doi:http://dx.doi.org/10.1159/000499878
23. Junarta J, Vivekanad JHA, Banerjee D. Insight into the impact of vitamin D on cardiovascular outcomes in chronic kidney disease. Nephrology. 2019; 24:781-90. Doi:https://doi.org/10.1111/nep.13569
24. Jean G, Souberbielle JC, Chazot C. Vitamin D in Chronic Kidney Disease and Dialysis Patients. Nutrients. 2017; 9(4) Doi:https://doi.org/10.3390/nu9040328
25. Kidney Disease: Improving Global Outcomes (KDIGO). KDIGO clinical practice guidelines for the diagnosis, evaluation, prevention and treatment of chronic kidney diseasemineral and bone disorder (CKD-MBD). KidneyIntSuppl. 2017;7:1-59
26. Matsumoto AK, Maes M, Michelin AP, Soares AE, Semeão LO, Godeny P, et al. Vitamin D deficiency is not associated with increased oxidative stress in chronic kidney disease pre-dialysis patients. Braz J Nephrol. 2020;42(4):420-8 Doi: https://doi.org/10.1590/2175-8239-jbn-2019-0156
27. Liu WC, Zheng CM, Lu CL et al: Vitamin D and immune function in chronic kidney disease. ClinChim Acta. 2015; 450:135-44. Doi: https://doi.org/10.1016/j.cca.2015.08.011
28. Jorge AJL, Cordeiro JR, Rosa MLG, Bianchi DBC. Deficiência da Vitamina D e Doenças Cardiovasculares Int J Cardiovasc Sci.2018; [online].aheadprint, PP.0-0 Doi:https://doi.org/10.5935/2359-4802.20180025
2. Bastos MG, Kirsztajn GM. Chronickidneydisease: importanceofearlydiagnosis, immediatereferralandstructuredinterdisciplinary approach to improve outcomes in patientsnotyetondialysis. JBrasNefrol. 2011; 13(4): 93-108. Doi: http://dx.doi.org/10.1590/S010128002011000100013
3. Pereira ERS, Pereira ADC, Andrade GB, Naghenetti AV, Pinto FKMS, Batista SR, et al. Prevalenceofchronic renal disease in adultsattendedbythe Family healthstrategy. J BrasNefrol. 2016; 38(1): 22-30. Doi: http://dx.doi.org/10.5935/0101-2800.20160005
4. Alani H, Tamimi A, Tamimi N. Cardiovascular co-morbidity in chronic kidney disease: Current knowledge and future research needs.World J Nephrol. 2014; 13(3):156-168. Doi:10.5527 / wjn.v3.i4.156
5. Monteiro Junior FDC, Mandarino, NR, Salgado, JVL, Lages JS, Filho NS. Deficiência de Vitamina D: um Novo Fator de Risco Cardiovascular?.RevBrasCardiol. 2014; 12(2): 356-365. Disponível em: http://www.rbconline.org.br/artigo/deficiencia-de-vitamina-d-um-novo-fator-de-risco-cardiovascular/
6. Zheng Z, Shi H, Jia J, Li D, Lin S. Vitamin D supplementation and mortality risk in chronic kidney disease: a meta-analysis of 20 observational studies. BMC Nephrol. 2013; 14(3): 1-13. Doi: 10.1186/1471-2369-14-199
7. Cozzolino M, Covic A, Placencia BM, Konstantinos X. Treatment failure of active vitamin D therapy in chronic kidney disease: Predictive factors. Am J Nephrol. 2015; 42(3):228–236. Doi:https://doi.org/10.1159/000441095
8. Mendes KDS, Silveira RCCP, Galvão CM. Use ofthebibliographicreference manager in theselectionofprimarystudies in integrativereviews. Texto contexto - enferm. [Internet]. 2019 [cited 2020 July 20] ; 28: e20170204. Doi: http://dx.doi.org/10.1590/1980-265x-tce-2017-0204
9. Melnyk BM, Finout-Overholt E. Evidence-based practice in nursing & healthcare: a guide to best practice. CritCare Nurse. 2014;34(3):174- 178.
10. Polit DF, Beck CT. Fundamentos de pesquisa em enfermagem: avaliação de Evidências para a Prática da Enfermagem. 9a ed. Porto Alegre (RS): Artmed;2018.
11. Duranton F, Ortiz MER, Duny Y, Rodriguez M, Daurès P, Argilés A. Vitamin D Treatment and Mortality in Chronic Kidney Disease: A Systematic Review and Meta-Analysis. Am J Nephrol. 2013;239–248. Doi: http://dx.doi.org/10.1159/000346846
12. Filho AJI, Melamed ML. Vitamin D andKidneyDisease. Whatweknowandwhatwe do notknowJ BrasNefrol. 2013;323-331. Doi: http://dx.doi.org/10.5935/0101-2800.20130051
13. Mann MC, Hoobs AJ, Hemmelgarn BR, Roberts DJ, Ahmed SB, Rabi DM. Effect of oral vitamin D analogs on mortality and cardiovascular outcomes among adults with chronic kidney disease: a meta-analysis. ClinKidney J. 2014;41–48. Doi: http://dx.doi.org/10.1093/ckj/sfu122
14. Parikh C, Gutgarts V, Eisenberg E, Melamed ML. Vitamin D and Clinical Outcomes in Dialysis. Semin Dial. 2014; 28(6):604–609. Doi:http://dx.doi.org/10.1111/sdi.12446
15. Ferreira A, Aires I, Nolasco F, Machado D, Macário F, Neves PL, et al. Benefits of selective vitamin D receptor activators in kidney transplanted patients. Port J NephrolHypert. 2015; 29(3):194-206. Disponível em: http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S087201692015000300003&lng=en.
16. Sekercioglu N, Busse JW, Sekercioglu MF, Agarwal A, Shaikh S, Lopes LC, et al. Cinacalcet versus standard treatment for chronic kidney disease: a systematic review and metaanalysis. RenFail. 2016; 38(6):857–874. Doi: http://dx.doi.org/10.3109/ 0886022X.2016.1172468
17. Magalhães LP, Reis LMD, Graciolli FG, Pereira BJ, Oliveira RBD, Souza AALD, et al. Predictive Factors of One-Year Mortality in a Cohort of Patients Undergoing Urgent-Start Hemodialysis. PloSOne. 2017; 1(3):1-8. Disponível em: https://observatorio.fm.usp.br/handle/OPI/18996
18. Hou YC, Liu WC, Zheng CM, Yen TH, Lu KC. Role of Vitamin D in Uremic Vascular Calcification. BioMedRes.Int. 2017; 1-11. DOI: https://doi.org/10.1155/2017/2803579
19. Shardlow A, Mclntyre NJ, Fluck RJ, Mclntyre CW, Taal MW. Associations of fibroblast growth factor 23, vitamin D and parathyroid hormone with 5 year outcomes in a prospective primary care cohort of people with chronic kidney disease stage 3. BMJ Open. 2017; 28(4): 83-92. Doi: http://dx.doi.org/10.1136/bmjopen-2017-016528
20. Hamano T. Vitamin D and renal outcome: the fourth outcome of CKD-MBD? Oshima AwardAddress 2015. J ClinExpNephrol .2018; 22(3): 249-256. Doi: http://dx.doi.org/10.1007/s10157-017-1517-3
21. Brzozka AG, Franzyck B, Ryzs AC, Olszewski R, Ryzs J. Impact of Vitamin D on the Cardiovascular System in Advanced Chronic Kidney Disease (CKD) and Dialysis Patients. Nutrients. 2018;10(4):709-718. Doi:http://dx.doi.org/10.3390/nu10060709
22. Chen X, Lu YP, Luo T, Wu HW, Cai SF, Tian M, et al. Free 25-Vitamin D Is Correlated with Cardiovascular Events in Prevalent Hemodialysis Patients but Not with Markers of Renal Mineral Bone Disease. KidneyBlood Press Res. 2019;44(2):344-353.Doi:http://dx.doi.org/10.1159/000499878
23. Junarta J, Vivekanad JHA, Banerjee D. Insight into the impact of vitamin D on cardiovascular outcomes in chronic kidney disease. Nephrology. 2019; 24:781-90. Doi:https://doi.org/10.1111/nep.13569
24. Jean G, Souberbielle JC, Chazot C. Vitamin D in Chronic Kidney Disease and Dialysis Patients. Nutrients. 2017; 9(4) Doi:https://doi.org/10.3390/nu9040328
25. Kidney Disease: Improving Global Outcomes (KDIGO). KDIGO clinical practice guidelines for the diagnosis, evaluation, prevention and treatment of chronic kidney diseasemineral and bone disorder (CKD-MBD). KidneyIntSuppl. 2017;7:1-59
26. Matsumoto AK, Maes M, Michelin AP, Soares AE, Semeão LO, Godeny P, et al. Vitamin D deficiency is not associated with increased oxidative stress in chronic kidney disease pre-dialysis patients. Braz J Nephrol. 2020;42(4):420-8 Doi: https://doi.org/10.1590/2175-8239-jbn-2019-0156
27. Liu WC, Zheng CM, Lu CL et al: Vitamin D and immune function in chronic kidney disease. ClinChim Acta. 2015; 450:135-44. Doi: https://doi.org/10.1016/j.cca.2015.08.011
28. Jorge AJL, Cordeiro JR, Rosa MLG, Bianchi DBC. Deficiência da Vitamina D e Doenças Cardiovasculares Int J Cardiovasc Sci.2018; [online].aheadprint, PP.0-0 Doi:https://doi.org/10.5935/2359-4802.20180025
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2021-03-22
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Artigos de revisão
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Deficiência de vitamina D e mortalidade cardiovascular na doença renal crônica: revisão integrativa. (2021). Ciência, Cuidado E Saúde, 20. https://doi.org/10.4025/ciencuidsaude.v20i0.50127
