Study on the profile of the analgesic therapy used in postoperative pain of hemorrhoidectomy - DOI: 10.4025/cienccuidsaude.v7i4.6624

Abstract

In the context of analgesic therapy, the characteristic of the medicine represents an important variable that helps to predict the potential of interaction of each agent. The purpose this study was to analyze the therapeutic profile of medicines used in the postoperative period (PO) by patients submitted to hemorrhoidectomy. These profiles were divided into the following categories: therapeutic classification, adverse drug reactions and drug interaction potential. This descriptive study comprises 246 medical prescriptions of adult patients hospitalized between 2002 and 2004 in a private hospital of Sao Paulo. There was predominance of female patients (54.6%), whose average age was 44.4 years. The Alpha system was used for the therapeutic classification of medicines. Data was analyzed through descriptive statistics. The class of analgesics (46.2%) and medicine with action in the digestion system (46,1%) had been used. Dypirone (83.7%) and lactulose (70.3%) were among the most prescribed medicines. About one third (38.5%) of the medicines presented interactive potential, with prominence for enzymatic inhibitors (60%) classified as precipitants, which had been used as adjuvant in the therapy. The nervous and gastrointestinal systems potentially were most affected by the adverse drug reactions, representing 69.2%. The understanding of the pharmacologic profile of medicines, as well as the pharmacokinetic, adverse drug reactions, mechanism of action are essential to prevent iatrogenic response in patients, mainly when they are exposed to polypharmacy.