Pesticide exposure and acute lymphocytic leukemia in children: a scope review

Keywords: Agrochemicals. Child. Precursor Cell Lymphoblastic Leukemia-Lymphoma.

Abstract

Introduction: Acute Lymphocytic Leukemia (ALL) is a type of cancer that affects the hematopoietic process and is directly related to genetic and environmental factors. Objective: To identify in the literature the existence of an association between exposure to pesticides and the development of Acute Lymphocytic Leukemia in children in the national and international scenario. Methods: A scoping review was carried out in the LILACS, IBECS, MEDLINE, BDENF, CINAHL databases, and Cochrane and Scielo and Google Scholar libraries. Production related to pesticide exposure and the development of Acute Lymphocytic Leukemia in children were included. Results: The review had 22 studies published from 2008 to 2017. The association of pesticide exposure with the development of childhood ALL was due to maternal exposure to domestic pesticides in the pre-conception, gestational period, and the child's exposure to domestic pesticides in early childhood. Conclusion: The results allowed us to identify publications on the association between the use of pesticides and the development of Acute Lymphocytic Leukemia in children. However, there is a need for further studies on children's exposure to domestic pesticides, knowledge of their toxicity, and damage to human health, as well as measures to reduce its use.

Downloads

Download data is not yet available.

Author Biographies

Juliana Vicente, Escola de Enfermagem da Universidade Federal do Rio Grande do Sul

Enfermeira. Porto Alegre, Rio Grande do Sul, Brasil.  

Deise Lisboa Riquinho , Escola de Enfermagem da Universidade Federal do Rio Grande do Sul

Enfermeira. Doutora em Saúde Pública. Professora Adjunta da Escola de Enfermagem da Universidade Federal do Rio Grande do Sul. Porto Alegre, Rio Grande do Sul, Brasil. 

Carlise Rigon Dalla Nora, Universidade Federal do Rio Grande do Sul

Enfermeira. Doutora em Enfermagem. Professora Adjunta da Escola de Enfermagem da Universidade Federal do Rio Grande do Sul. Porto Alegre, Rio Grande do Sul, Brasil.  

Adalvane Nobres Damaceno , Escola de Enfermagem da Universidade Federal do Rio Grande do Sul

Enfermeiro. Doutorando em Enfermagem pelo Programa de Pós-Graduação da Universidade Federal do Rio Grande do Sul. Porto Alegre, Rio Grande do Sul, Brasil. 

Lucia Helena Donini Souto , Escola de Enfermagem da Universidade Federal do Rio Grande do Sul

Enfermeira. Porto Alegre, Rio Grande do Sul, Brasil. 

References

Malta DC, Oliveira TP, Santos MAS, Andrade SSCA, Silva MMA. Progress with the Strategic Action Plan for Tackling Chronic Non-Communicable Diseases in Brazil, 2011-2015.Epidemiologia e Serviços de Saúde. 2016, 25 (2): 373-390. DOI: http://dx.doi.org/10.5123/s1679-49742016000200016.

Silva MJS (org.). ABC do câncer: abordagens básicas para o controle do câncer. 3ª ed. Rio de Janeiro: Inca, 2017.

Landrigan PJ, Miller MD, Marty MA. Children’s environmental health. Pediatric Clinics of North America. 2016, 16 (1): 1–9. DOI: https://doi.org/10.1016/j.acap.2015.10.002

Silva CS, Sousa RR, Cardoso RO. Leukemia Acute Lymphoids in Children and their Complications. RevInicCient e Ext. [Internet]. 2018 jun. [citado 03 set 2020];1(2):109-13]. Disponível em: URL:https://revistasfacesa.senaaires.com.br/index.php/iniciacao-cientifica/article/view/58

Carneiro FF, Augusto LGS,Rigotto RM, Friedrich K, Búrigo AC (Org.). Dossiê Abrasco: um alerta sobre os impactos dos agrotóxicos na saúde. Rio de Janeiro: EPSJV; São Paulo: Expressão Popular, 2015.

Lima GS, Chagas RDB, Macedo KPC, Silva MC, Leal BS, Vaz JLS et al.Caracterização das intoxicações por produtos de uso domiciliar na cidade de Teresina Piauí.Revista Eletrônica Acervo Saúde. 2020, (55): e666. DOI: https://doi.org/10.25248/reas.e666.2020

Riquinho DL, Hennington EA. Sistema integrado de produção do tabaco: saúde, trabalho e condições de vida de trabalhadores rurais no Sul do Brasil. Cad. Saúde Pública 2016. 32(12): e00072415. DOI: http://dx.doi.org/10.1590/0102-311x00072415

Silva MGP, Bedor CNG, Alencar KMCA, Moura LTR. Trends in morbidity and mortality due to child and adolescent cancer in a center of irrigated fruit culture. Cad. saúde colet. 2018, 26(1): 38-44. DOI: http://dx.doi.org/10.1590/1414-462x201800010477

Finkler MG, Battisti IDE, Anastácio ZFC. Exposição de Crianças a Agrotóxicos: uma revisão integrativa. Rev de Psic. 2019, (2):147-156. DOI: https://doi.org/10.17060/ijodaep.2019.n2.v1.1683

Pelaez V, Silva RL, Guimarães TA, Dal Ri F, Teodorovicz T. (des)coordenação de políticas para a indústria de agrotóxicos no Brasil. Revista Brasileira de Inovação, 2015;14 (esp.):153-178. DOI: https://doi.org/10.20396/rbi.v14i0.8649104

Brisson GD, Alves LR, Pombo-de-Oliveira MS. Genetic susceptibility in childhood acute leukaemias: a systematic review. Ecancer Medical Science. 2015;9(539):1-28. DOI: http://dx.doi.org/10.3332/ecancer.2015.539

Arksey H, O’Malley L. Scoping studies: towards a methodological framework. Int J Soc Res Methodol. 2005; 8(1):19-32. DOI:https://doi.org/10.1080/1364557032000119616

Joanna Briggs Institute Reviewers. Methodology for JBI Scoping Reviews Manual 2015. The University of Adelaide, South Australia. Joanna Briggs Institute Reviewers, 2015.

World Health Organization (WHO). Child and adolescent health and development. Geneva, 2004.

Moher D, Liberati A, Tetzlaff J, Altman DG. The PRISMA Group (2009). Preferred Reportng Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLos Med. 2009; 6(7):e1000097. DOI: https://doi.org/10.1371/journal.pmed.1000097

Silva CAM, Frunchtengarten L. Riscos químicos ambientais à saúde da criança. Jornal de Pediatria. 2005; 81(5): 205-211. DOI: https://doi.org/10.4025/cienccuidsaude.v8i1.7772

Lira SVG, Silva JG, Abreu RNDC, Moreira DP, Vieira LJES, Frota MA. Intoxicações por pesticidas em crianças, adolescentes e jovens no município de Fortaleza (CE). Ciência, Cuidado e Saúde. 2009; 8(1):48-55. DOI:https://doi.org/10.4025/cienccuidsaude.v8i1.7772

Werneck GL, Hasselmann MH. Intoxicações exógenas em crianças menores de seis anos atendidas em hospitais da região metropolitana do Rio de Janeiro. Revista da Associação Médica Brasileira, 2009; 55(3): 302-307. DOI:http://dx.doi.org/10.1590/S0104-42302009000300023.

Wigle DT, Turner MC, Krewski DA. Systematic Review and Meta-analysis of Childhood Leukemia and Parental Occupational Pesticide Exposure. Environmental Health Perspectives. 2009; 117(10): 1505-1513. DOI: http://dx.doi.org/10.1289/ehp.0900582

Wiemels JL, Kang M, Chang JS , Zheng L , Kouyoumji C, Zhang L et al. Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia. Blood Cells, Molecules, And Diseases, 2010; 45(3):186-191. DOI: https://dx.doi.org/10.1016%2Fj.bcmd.2010.07.007

Chokkalingam AP, Metayer C, Scelo GA , Chang JS, Urayama KY, Aldrich MC et al. Variation in xenobiotic transport and metabolism genes, household chemical exposures, and risk of childhood acute lymphoblastic leukemia. Cancer Causes & Control. 2012; 23(8): 1367-1375. DOI: https://doi.org/10.1007/s10552-012-9947-4

Rudant J, Orsi L, Bonaventure A, Goujon-Bellec S, Baruchel A, Petit A et al. ARID5B, IKZF1 and Non-Genetic Factors in the Etiology of Childhood Acute Lymphoblastic Leukemia: The ESCALE Study. Plos One. 2015; 10(3): 121-348. DOI:https://doi.org/10.1371/journal.pone.0121348

Metayer C, Dahl G, Wiemels J, Miller M. Childhood Leukemia: A Preventable Disease. Pediatrics. 2016;138(1): 45-5. DOI:https://doi.org/10.1542/peds.2015-4268H

Hernández A, Menédez P. Linking Pesticide Exposure with Pediatric Leukemia: Potential Underlying Mechanisms. International Journal Of Molecular Sciences. 2016; 17(4): 461-461. DOI: http://dx.doi.org/10.3390/ijms17040461.

Rull P, Gunier R, Behren JV, Hertz A, Crouse V, Buffler PA et al. Residential proximity to agricultural pesticide applications and childhood acute lymphoblastic leukemia. Environmental Research.2009; 109(7): 891-899. DOI:https://doi.org/10.1016/j.envres.2009.07.014

Bailey HD, Infante-Rivard C, Metayer C, Clavel J, Lightfoot T, Kaatsch P et al. Home pesticide exposures and risk of childhood leukemia: Findings from the childhood leukemia international consortium. Int. J. Cancer. 2015; 137(11):2644-2663. DOI: https://doi.org/10.1002/ijc.29631

Whitehead TP, Metayer C, Wiemels JL, Singer AW, Miller MD. Childhood Leukemia and Primary Prevention. CurrProblPediatrAdolesc Health Care.2016; 46(10): 317-352. DOI: https://doi.org/10.1016/j.cppeds.2016.08.004

Soldin OP, Nsouly-Maktabi H, Genkinger JM, Loffredo CA, Ortega-Garcia, JA et al. Pediatric Acute Lymphoblastic Leukemia and Exposure to Pesticides. Therapeutic Drug Monitoring. 2009; 31(4): 495-501. DOI: https://doi.org/10.1097/FTD.0b013e3181aae982

Brisson GD, Alves LR, Pompo-de-Oliveira MS. Genetic susceptibility in childhood acute leukaemias: a systematic review. Ecancer medical science. 2015; 9(14):1-11. DOI: https://doi.org/10.3332/ecancer.2015.539

Castro AA, Prandi IG, Kuca K, Ramalho TC. Enzimas degradantes de organofosforados: Base molecular e perspectivas para biorremediação enzimática de agroquímicos. Ciência e Agrotecnologia. 2017; 41(5):471-482. DOI:http://dx.doi.org/10.1590/1413-70542017415000417

Mangas I, Vilanova E, Estévezc J, França TCC. Neurotoxic Effects Associated with Current Uses of Organophosphorus Compounds. Journal Of The Brazilian Chemical Society. 2016; 27(5): 809-825. DOI:http://dx.doi.org/10.5935/0103-5053.20160084

Camponogara S, Rodrigues IL, Dia GL, Moura LN, Viero CM, Miorin JD. Implications of pesticide use: perceptions of families of children with cancer. Revista de Pesquisa: Cuidado é Fundamental Online. 2017; 9(3):786-794. DOI:http://dx.doi.org/10.9789/2175-5361.2017.v9i3.786-794

Almeida MD, Cavendish TA, Bueno PC, Ervilha IC, Gregório LDS, Kanashiro NBO et al.The flexibilization of the Brazilian legislation on pesticides and the risks to human health: analysis of Bill of Law 3.200/2015. Cad. SaúdePública. 2017; 33(7):e00181016. DOI:https://doi.org/10.1590/0102-311x00181016

Nicolopoulou-Stamati P, Maipas S, Kotampasi C, Stamatis P, Hens L. Chemical Pesticides and Human Health: The Urgent Need for a New Concept in Agriculture. Frontiers In Public Health, 2016; 4(148):1-8. DOI:https://dx.doi.org/10.3389%2Ffpubh.2016.00148

Siqueira SL, Kruse MHL. Agrotóxicos y salud humana: contribución de losprofesionales de lasalud.Rev. Esc. Enferm. USP, 2008; 42(3): 584-590. DOI:http://dx.doi.org/10.1590/S0080-62342008000300024

Santos CV. Correlação entre exposição a pesticida e o desenvolvimento da Leucemia Linfocítica Aguda Infantil (LLA). 2013. 44 f. [Trabalho de Conclusão de Curso]. São Paulo (SP). Curso de Licenciatura em Ciências Biológicas. Instituto Federal de EducaçãoCiência e Tecnologia, 2013.

Van Maele-Fabry G, Gamet-Payrastre L, Lison D. Domestic pesticide exposure and leukemia risk in children and adolescents: updated systematic review and meta-analysis. Int J Hyg Environ Health. 2019; 222 (1): 49-67. DOI: https://doi.org/10.1016/j.ijheh.2018.08.004.

Hyland C, Gunier RB, Metayer C, Bates MN, Wesseling C, Mora AM. Maternal residential pesticide use and risk of childhood leukemia in Costa Rica. International Journal of Cancer. 2018; 143: 1295–1304. DOI: https://doi.org/10.1002/ijc.31522

Guniera RB, Kanga SA, Hammonda K, Reinierb K, Leac CS, Changd JS et al. A Task-based Assessment of Parental Occupational Exposure to Pesticides and Childhood Acute Lymphoblastic Leukemia. Environ Res. 2017; 156:57–62. DOI: https:/doi:10.1016/j.envres.2017.03.001

Hungaro AA, Correia LM, Silvino MCS, Rocha SM, Martins BF, Oliveira MLF. Pesticidepoisoning: recordsof a toxicologicalassistancesentinelservice.Cienc, Cuid e Saúde. 2015; 14(3):1362-1369. DOI:https://doi.org/10.4025/cienccuidsaude.v14i3.25119

Published
2020-12-10
How to Cite
Vicente, J., Lisboa Riquinho , D., Rigon Dalla Nora, C., Nobres Damaceno , A., & Donini Souto , L. H. (2020). Pesticide exposure and acute lymphocytic leukemia in children: a scope review. Ciência, Cuidado E Saúde, 19. https://doi.org/10.4025/ciencuidsaude.v19i0.50017
Section
Review articles