Studies about micronucleited eritrocites in mice treataded with anabolizantes

Abstract

Drugs as cobamamid and ubidecarenone have been used by different sportsmen as a treatment to gain fast muscular mass. Literature shows modulation of haematopoietic toxicity associated with these drugs. An evaluation of the results obtained in an in vivo study to assess the effectiveness of cobamamid and ubidecarenone administered to normal mice is discussed in this paper. The sample was compared with controls that received distilled water or cyclophosphamide. The haematopoietic toxicity was evaluated by MN(micronucleus) test in bone marrow cells. Statistical analysis with ANOVA and paired Student “t”and Tuckey “T” tests were used to determine the significance of MN polychromatic erythrocytis (PE) and normochromatic erythrocytes (NE) in different groups. Both isolated and associated drug administration revealed mutagenesis index effect as may be seen in the data table and those results require special caution for further studies.