STOCHASTIC DIFFUSION OF TACROLIMUS, CATALASE AND BACTERIAL BIOMASS IN FERMENTSCIBLE MEDIUM
Abstract
The cause for concern about health is fundamental in all areas of knowledge, particularly when it involves the invisible people to public policies, which depends on high-cost drugs, such as the immunosuppressant tacrolimus. The present work is directed to the theoretical investigation of the Brownian motion of tacrolimus, bacterial biomass and catalase, from fermentation via S. tsukubaensis, in a solution of fermentable broth and acetone (50 % v/v) at two different temperatures. Two-dimensional cartograms are presented to illustrate the random displacement of the analyzed species, using Langevin model as starts of approach. It is observed a greater dispersion of tacrolimus in relation to the other solutes, as well as the increase in dispersion with increasing temperature of the diffusive medium.
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References
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[9] BERTAN, A. S.; SILVA, S. C. M.; CREMASCO, M. A. Production of tacrolimus using coconut oil as an alternative to glucose. Acta Scientarium Technology, v. 43, n. 1, p. e55721, set. 2021a.
[10] MURAMATSU, H.; NAGAI, K. Streptomyces tsukubaensis sp. nov., a producer of the immunosuppressant tacrolimus. The Journal of Antibiotics, v. 66, p. 251 – 254, 2013.
[11] MISHRA, A.; VERMA, S. Optimization of process parameters for tacrolimus (FK 506) production by new isolate of Streptomyces sp. using response surface methodology. Journal of Biochemical Technology, v. 3, n. 4, p. 419 – 425, out. 2012.
[12] WANG, J.; LIU, H.; HUANG, D.; JIN, L.; WANG, C.; WEN, J. Comparative proteomic and metabolomics analysis of Streptomyces tsukubaensis reveals the metabolic mechanism of FK506 overproduction by feeding soybean oil. Applied Microbiology and Biotechnology, v. 101, p. 2447 – 2465, mar. 2017.
[13] KAUSHAL, J.; MEHANDIA, S.; SINGH, G.; RAINA, A.; ARYA, S. K. Catalase enzyme: Application in bioremediation and food industry. Biocatalysis and Agricultural Biotecnology, v. 16, p. 192 – 199, out. 2018.
[14] CREMASCO, M. A. Difusão mássica. São Paulo: Blucher, 2019. 284 p.
[15] CREMASCO, M. A. Fundamentos de transferência de massa. 3. ed. São Paulo: Blucher, 2015. 460 p.
[16] MEDVED, A.; DAVIS, R.; VASQUEZ, P. A. Understanding fluid dynamics from Langevin and Fokker–Planck equations. Fluids, v. 5, n. 1, p. 40 – 63, mar. 2020.
[17] MORÃO, A. M.; NUNES, J. C.; SOUSA, F.; de AMORIM, M. T. P.; ESCOBAR, I. C.; QUEIROZ, J. A. Development of a model for membrane filtration of long and flexible macromolecules: application to predict dextran and linear DNA rejections in ultrafiltration. Journal of Membrane Science, v. 336, p. 61 – 70, mar. 2009.
[18] CREMASCO, M. A. Operações unitárias em sistemas particulados e fluidomecânicos. 3. ed. São Paulo: Blucher, 2018. 424 p.
[19] GAVEAU, A.; COETSIER, C.; ROQUES, C.; BACCHIN, P.; DAGUE, E.; CAUSSERAND, C. Bacteria transfer by deformation through microfiltration membrane. Journal of Membrane Science, v. 523, p. 446 – 455, fev. 2017.
[20] BERTAN, A. S.; AYALA, J. S; CASTILHO, G. J; CREMASCO, M. A. Reological models of broth from fermentation via Streptomyces tsukubaensis to obtain tacrolimus. In: 23°. Congresso Brasileiro de Engenharia Química, Rio Grande do Sul. Anais [ ]. Gramado: COBEQ, 2021b.
[2] CURVELLO NETO, A. L.; COSTA, M. C.; BRUDEMANN, E. A.; YU, L. Atualização em insuficiência renal aguda: nefrotoxidade aguada de drogas imunossupressoras. Brazilian Journal of Nephrology, v. 22, n.2, p. 114 – 120, jun. 2000.
[3] GARCIA, S. C.; LOPES, L. S.; SCHOTT, K. L; BECK, S. T; POMBLUM, V, J. Ciclosporina A e tacrolimus: uma revisão. Jornal Brasileiro de patologia e Medicina Laboratorial, v. 40, n. 6, p. 393 – 401, dez. 2004.
[4] SANCHEZ, A. R; SHERIDAN, P. J.; ROGERS, R.S. Successful treatment of oral lichen planus-like chronic graft-versus-host disease with topical tacrolimus: a case report. Journal of Periodontology, v. 75, n. 4, p. 613 – 619, abr. 2004.
[5] ECKSTEIN, L. A.; VAN QUILL, K. R.; BUI, S. K.; UUSITALO, M. S.; O’BRIEN, J. M. Cyclosporin a inhibits calcineurin/nuclear factor of activated T-cells signaling and induces apoptosis in retinoblastoma cells. Invest Ophthalmology and Visual Science, v. 46, n. 3, p. 782 –790, mar. 2005.
[6] GOMES, C. T. V.; CASTRO, I. M. B. D.; COLLI, Guilherme. M.; GOZZANO, M, C. C.; BELTRÃO, A. R; SHIGA, A. S.; RAMOS, V. C. S. Dermatomiosite juvenil e tacrolimus: eficácia nas lesões cutâneas refratárias. In: 34°. Congresso da SUMEP, São Paulo. Anais [ ]. Sorocaba: SUMEP, 2018.
[7] TAMLER, C.; DUQUE-ESTRADA, B.; OLIVEIRA, P. A.; AVELLEIRA, J. C. R. Pomada de tacrolimus 0,1% no tratamento de vitiligo: serie de casos. Anais Brasileiro de Dermatologia, v. 86, n. 1, p. 167 – 169, out. 2011.
[8] CHAUDHARI, N. D.; TALANIKER, H. V.; GUPTA, S.; GUPPA, A.; DESMUKH, P.; RIZVI, A. Topical tacrolimus: A boom to dermatology. Journal of Phamaceutical and Biomedical Sciences, v. 4, n. 3, p. 188 – 192, nov. 2012.
[9] BERTAN, A. S.; SILVA, S. C. M.; CREMASCO, M. A. Production of tacrolimus using coconut oil as an alternative to glucose. Acta Scientarium Technology, v. 43, n. 1, p. e55721, set. 2021a.
[10] MURAMATSU, H.; NAGAI, K. Streptomyces tsukubaensis sp. nov., a producer of the immunosuppressant tacrolimus. The Journal of Antibiotics, v. 66, p. 251 – 254, 2013.
[11] MISHRA, A.; VERMA, S. Optimization of process parameters for tacrolimus (FK 506) production by new isolate of Streptomyces sp. using response surface methodology. Journal of Biochemical Technology, v. 3, n. 4, p. 419 – 425, out. 2012.
[12] WANG, J.; LIU, H.; HUANG, D.; JIN, L.; WANG, C.; WEN, J. Comparative proteomic and metabolomics analysis of Streptomyces tsukubaensis reveals the metabolic mechanism of FK506 overproduction by feeding soybean oil. Applied Microbiology and Biotechnology, v. 101, p. 2447 – 2465, mar. 2017.
[13] KAUSHAL, J.; MEHANDIA, S.; SINGH, G.; RAINA, A.; ARYA, S. K. Catalase enzyme: Application in bioremediation and food industry. Biocatalysis and Agricultural Biotecnology, v. 16, p. 192 – 199, out. 2018.
[14] CREMASCO, M. A. Difusão mássica. São Paulo: Blucher, 2019. 284 p.
[15] CREMASCO, M. A. Fundamentos de transferência de massa. 3. ed. São Paulo: Blucher, 2015. 460 p.
[16] MEDVED, A.; DAVIS, R.; VASQUEZ, P. A. Understanding fluid dynamics from Langevin and Fokker–Planck equations. Fluids, v. 5, n. 1, p. 40 – 63, mar. 2020.
[17] MORÃO, A. M.; NUNES, J. C.; SOUSA, F.; de AMORIM, M. T. P.; ESCOBAR, I. C.; QUEIROZ, J. A. Development of a model for membrane filtration of long and flexible macromolecules: application to predict dextran and linear DNA rejections in ultrafiltration. Journal of Membrane Science, v. 336, p. 61 – 70, mar. 2009.
[18] CREMASCO, M. A. Operações unitárias em sistemas particulados e fluidomecânicos. 3. ed. São Paulo: Blucher, 2018. 424 p.
[19] GAVEAU, A.; COETSIER, C.; ROQUES, C.; BACCHIN, P.; DAGUE, E.; CAUSSERAND, C. Bacteria transfer by deformation through microfiltration membrane. Journal of Membrane Science, v. 523, p. 446 – 455, fev. 2017.
[20] BERTAN, A. S.; AYALA, J. S; CASTILHO, G. J; CREMASCO, M. A. Reological models of broth from fermentation via Streptomyces tsukubaensis to obtain tacrolimus. In: 23°. Congresso Brasileiro de Engenharia Química, Rio Grande do Sul. Anais [ ]. Gramado: COBEQ, 2021b.
Published
2023-05-17
How to Cite
Suzin Bertan, A., & Cremasco, M. A. (2023). STOCHASTIC DIFFUSION OF TACROLIMUS, CATALASE AND BACTERIAL BIOMASS IN FERMENTSCIBLE MEDIUM. Revista Tecnológica, 31, 112-120. https://doi.org/10.4025/revtecnol.v31i0.65198
Section
Articles
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