The effect of Î²-cyclodextrin in the photochemical stability of propranolol hydrochloride in aqueous solution

Tathiane Lilian Ansolin; Reinaldo Aparecido Bariccatti; Mauricio Ferreira da Rosa; Cleber Antonio Lindino

doi:10.4025/actascitechnol.v36i2.17554

The effect of Î²-cyclodextrin in the photochemical stability of propranolol hydrochloride in aqueous solution

Authors

Tathiane Lilian Ansolin Universidade Estadual do Oeste do Paraná
Reinaldo Aparecido Bariccatti Universidade estadual do Oeste d Paraná
Mauricio Ferreira da Rosa Universidade Estadual do Oeste do Paraná
Cleber Antonio Lindino Universidade Estadual do Oeste do Paraná

DOI:

https://doi.org/10.4025/actascitechnol.v36i2.17554

Keywords:

nanocavity, drug, photochemical

Abstract

The degradation of propranolol hydrochloride (1-isopropylamino-3-(naphthoxy)-2-propranolol) in an aqueous solution was analyzed when irradiated by light UV, with and without Î²-cyclodextrin. There was an increase in the compoundÂ´s photostability in nanocavity when compared with the drug without the cyclodextrins´ cavity. First order kinetic model was employed for the degradation of propranolol in aqueous media and in cyclodextrins´ cavity. The kinetic parameter was obtained by the drugÂ´s absorption and electronic fluorescence. As a rule, encapsulation of propranolol in Î²-cyclodextrin decreases photodegradation speed by 53%.

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Published

2014-04-04

How to Cite

Ansolin, T. L., Bariccatti, R. A., Rosa, M. F. da, & Lindino, C. A. (2014). The effect of Î²-cyclodextrin in the photochemical stability of propranolol hydrochloride in aqueous solution. Acta Scientiarum. Technology, 36(2), 337–340. https://doi.org/10.4025/actascitechnol.v36i2.17554

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Issue

Vol. 36 No. 2 (2014)

Section

Chemistry

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