Caracterização e qualificação de diclofenaco de sódio como padrão secundário - doi: 10.4025/actascitechnol.v34i1.11654

Paulo Roberto Stoef; Silvane Guzzi; Marla Suzane Carletto; Viviane da Silva Lobo; Mauricio Ferreira da Rosa

doi:10.4025/actascitechnol.v34i1.11654

Characterization and qualification of diclofenac sodium as a secondary standard - doi: 10.4025/actascitechnol.v34i1.11654

Authors

Paulo Roberto Stoef Indústria Farmacêutica Prati-Donaduzzi & Companhia Ltda
Silvane Guzzi Indústria Farmacêutica Prati-Donaduzzi & Companhia Ltda
Marla Suzane Carletto Indústria Farmacêutica Prati-Donaduzzi & Companhia Ltda
Viviane da Silva Lobo Universidade Tecnológica Federal do Paraná
Mauricio Ferreira da Rosa Universidade Estadual do Oeste do Paraná

DOI:

https://doi.org/10.4025/actascitechnol.v34i1.11654

Keywords:

infrared spectroscopy, reference standard, HPLC

Abstract

This paper aimed to characterize and qualify a secondary standard of diclofenac sodium as a reference standard in the quality control of medicines. The identity of the candidate was confirmed through infrared spectroscopy and the content (99.63%) determined by high performance liquid chromatography (HPLC) by comparing with the compendial primary standard. The quality of the secondary standard was also supported by redox titration in non-aqueous media, related substances and UV spectrum by HPLC.

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Author Biographies

Paulo Roberto Stoef, Indústria Farmacêutica Prati-Donaduzzi & Companhia Ltda

Prati-Donaduzzi Industria Farmaceutica

Viviane da Silva Lobo, Universidade Tecnológica Federal do Paraná

Tecnologia em Processos Químicos - UTFPR/Toledo (PR)

Mauricio Ferreira da Rosa, Universidade Estadual do Oeste do Paraná

GIPeFEA - Grupo Interdisciplinar de Fotoquímica e Eletroanalítica Ambiental/Química/Unioeste-Toledo (PR)

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Published

2011-07-08

How to Cite

Stoef, P. R., Guzzi, S., Carletto, M. S., Lobo, V. da S., & Rosa, M. F. da. (2011). Characterization and qualification of diclofenac sodium as a secondary standard - doi: 10.4025/actascitechnol.v34i1.11654. Acta Scientiarum. Technology, 34(1), 89–95. https://doi.org/10.4025/actascitechnol.v34i1.11654

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Issue

Vol. 34 No. 1 (2012)

Section

Chemistry

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