<b>The effect of β-cyclodextrin in the photochemical stability of propranolol hydrochloride in aqueous solution<b>

Autores

  • Tathiane Lilian Ansolin Universidade Estadual do Oeste do Paraná
  • Reinaldo Aparecido Bariccatti UNIOESTE
  • Mauricio Ferreira da Rosa Universidade Estadual do Oeste do Paraná
  • Cleber Antonio Lindino Universidade Estadual do Oeste do Paraná

DOI:

https://doi.org/10.4025/actascitechnol.v36i2.17554

Palavras-chave:

nanocavity, drug, photochemical

Resumo

The degradation of propranolol hydrochloride (1-isopropylamino-3-(naphthoxy)-2-propranolol) in an aqueous solution was analyzed when irradiated by light UV, with and without β-cyclodextrin. There was an increase in the compound´s photostability in nanocavity when compared with the drug without the cyclodextrins´ cavity. First order kinetic model was employed for the degradation of propranolol in aqueous media and in cyclodextrins´ cavity. The kinetic parameter was obtained by the drug´s absorption and electronic fluorescence. As a rule, encapsulation of propranolol in β-cyclodextrin decreases photodegradation speed by 53%.

 

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Publicado

2014-04-04

Como Citar

Ansolin, T. L., Bariccatti, R. A., Rosa, M. F. da, & Lindino, C. A. (2014). <b>The effect of β-cyclodextrin in the photochemical stability of propranolol hydrochloride in aqueous solution<b>. Acta Scientiarum. Technology, 36(2), 337–340. https://doi.org/10.4025/actascitechnol.v36i2.17554

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Quí­mica

 

0.8
2019CiteScore
 
 
36th percentile
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0.8
2019CiteScore
 
 
36th percentile
Powered by  Scopus

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