<b>Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometry

Authors

  • Sarah Moherdaui Martins EMS Indústria Farmacêutica
  • Mauricio Ferreira da Rosa Universidade Estadual do Oeste do Paraná
  • Fábio Souza Prati, Donaduzzi & Cia Ltda. Medicamentos Genéricos
  • Vanderson Galan Prati, Donaduzzi & Cia Ltda. Medicamentos Genéricos
  • Viní­cius Muller Prati, Donaduzzi & Cia Ltda. Medicamentos Genéricos
  • Itamar Francisco Andreazza Universidade Federal do Paraná

DOI:

https://doi.org/10.4025/actascitechnol.v40i1.30754

Keywords:

biphasic release, multiparticulate system, pellets.

Abstract

 

Hypertension is one of the most important mortality risks in the world and is considered the leading cause of deaths associated with cardiovascular disease. In an attempt to improve the treatments and apply them to a large number of disorders, a propranolol hydrochloride (Prop) based medicine it was developed in our laboratory, employing a multiparticulate system which operates in a biphasic manner, one portion of immediate and other of modified release. This study aimed at developing and validating a suitable method to quantify this new version of the drug using UV spectrophotometry, following what is recommended in RE 899/2003. The results showed that the method employed was linear, accurate, precise and robust in the range of 0.8 to 96.0 μg mL-1, which allows it for routine use in quality control laboratories.

 

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Author Biographies

Sarah Moherdaui Martins, EMS Indústria Farmacêutica

Post-graduation Program on Pharmaceutical Sciences, State University of Western Paraná, 85819-110 Cascavel - PR, Brazil.
Departament of Research, Development and Inovation, Prati-Donaduzzi e Cia Ltda, 85903-630 Toledo - PR, Brazil.

Mauricio Ferreira da Rosa, Universidade Estadual do Oeste do Paraná

Post-graduation Program on Pharmaceutical Sciences, State University of Western Paraná, 85819-110 Cascavel - PR, Brazil

Fábio Souza, Prati, Donaduzzi & Cia Ltda. Medicamentos Genéricos

Departament of Research, Development and Inovation, Prati-Donaduzzi e Cia Ltda, 85903-630 Toledo - PR, Brazil.

Vanderson Galan, Prati, Donaduzzi & Cia Ltda. Medicamentos Genéricos

Departament of Research, Development and Inovation, Prati-Donaduzzi e Cia Ltda, 85903-630 Toledo - PR, Brazil.

Viní­cius Muller, Prati, Donaduzzi & Cia Ltda. Medicamentos Genéricos

Departament of Research, Development and Inovation, Prati-Donaduzzi e Cia Ltda, 85903-630 Toledo - PR, Brazil.

Itamar Francisco Andreazza, Universidade Federal do Paraná

Departament of Pharmacy, Federal University of Paraná

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Published

2018-01-01

How to Cite

Martins, S. M., Rosa, M. F. da, Souza, F., Galan, V., Muller, V., & Andreazza, I. F. (2018). <b>Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometry. Acta Scientiarum. Technology, 40(1), e30754. https://doi.org/10.4025/actascitechnol.v40i1.30754

Issue

Vol. 40 (2018): Publicação Contí­nua

Section

Chemistry

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